Prolonged Mitogen-Activated Protein Kinase Kinase (MEK) Inhibition Induces Increase in Proteolysis and Compensatory Phosphorylation of MEK and Protein Kinase B (AKT) in Plexiform Neurofibroma Cells

Kyungmin Ji(Henry Ford Health System), Raymond R. Mattingly(Wayne State University)
Cells
February 28, 2026
10.3390/cells15050434
Cited by 0

Related Papers

Three-Dimensional Overlay Culture Models of Human Breast Cancer Reveal a Critical Sensitivity to Mitogen-Activated Protein Kinase Kinase Inhibitors
|Journal of Pharmacology and Experimental Therapeutics|2009|76
Activated Ras as a Therapeutic Target: Constraints on Directly Targeting Ras Isoforms and Wild-Type versus Mutated Proteins
|ISRN Oncology|2013|33
Gβγ subunits stimulate p21‐activated kinase 1 (PAK1) through activation of PI3‐kinase and Akt but act independently of Rac1/Cdc42
|FEBS Letters|2003|24