Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study

Jason L. Vassy; Anna Dornisch; Roshan Karunamuni; Michael Gatzen; Christopher J. Kachulis; Niall J. Lennon; Charles A. Brunette; Morgan E. Danowski; Richard L. Hauger; Isla P. Garraway; Adam S. Kibel; Kyung M. Lee; Julie A. Lynch; Kara N. Maxwell; Dmitry Ratner; Brent S. Rose; Craig C. Teerlink; George J. Xu; Sean E Hofherr; Katherine A Lafferty; Katie Larkin; Edyta Małolepsza; Candace Patterson; Diana M. Toledo; Jenny L. Donovan; Freddie C. Hamdy; Richard M. Martin; David Edgar Neal; E. C. Turner; Ole A Andreassen; Anders M. Dale; Ian G. Mills; Aswin Abraham; Jyotsna Batra; Judith Clements; Olivier Cussenot; C. Cybulski; Rosalind A. Eeles; Jay H. Fowke; Eli Marie Grindedal; Henrik Gronberg; Rob Hamilton; Jasmine Lim; Yong-Jie Lu; Robert J. MacInnis; C. Maier; Mucci La; Multigner Luc; Susan L. Neuhausen; Sune F. Nielsen; Marie-Élise Parent; Jong Y. Park; György Petrovics; Anna Plym; Azad Hassan Abdul Razack; B ROSENSTEIN; Johanna Schleutker; Karina Dalsgaard Sørensen; Paul A. Townsend; Ruth C. Travis; A. I. Vega; Catharine M. L. West; Fredrik Wiklund; Wei Zheng; Rosalind A. Eeles; Elizabeth K. Bancroft; Eva McGrowder; Z. Kote-Jarai; Mark N. Brook; Elizabeth C. Page; Jana McHugh; Holly Ni Raghallaigh; Denzil Robert James; Pardeep Kumar; Steve Hazell; Aslam Sohaib; Alexander Edwin Teixeira Dias; Christos Mikropoulos; Netty Kinsella; Declan Cahill; Elizabeth K. Bancroft; Elizabeth C. Page; D. Gareth Evans; Geoffrey J. Lindeman; Paul James; Lucy Side; Karina Rønlund; Brian T. Helfand; C. Cybulski; Kai‐Ren Ong; Monica Salinas; Jackie Cook; Kara N. Maxwell; Manuel R. Teixeira; Rosemarie Davidson; A. Liljegren; Ashraf Azzabi; Marc Tischkowitz; Ruth Cleaver; Julian Barwell; Neil K. Aaronson; Audrey Ardern-Jones; Chris H. Bangma; Elena Castro; David Dearnaley; Diana Eccles; Alison Falconer; Henrik Gronberg; Freddie C. Hamdy; Vincent Khoo; H. Lilja; Jan Lubiński; Christos Mikropoulos; A. Mitra; Judith Offman; Rennert Gad; Mohnish Suri; Christopher A. Haiman; Z. Kote-Jarai; Fredrick R. Schumacher; S. Benlloch; Ali Amin Al Olama; Ken Muir; S. I. Berndt; David V. Conti; Fredrik Wiklund; Stephen Chanock; Ying Wang; Catherine M. Tangen; Henrik Gronberg; Nora Pashayan; Demetrius Albanes; Stephanie J. Weinstein; Alicja Wolk; Catharine M. L. West; Géraldine Cancel-Tassin; Stella Koutros; David Edgar Neal; Freddie C. Hamdy; Rob Hamilton; SA Ingles; B ROSENSTEIN; Yongjie Lu; Graham G. Giles; Robert J. MacInnis; Adam S. Kibel; M Kogevinas; Kathryn L. Penney; Janet L. Stanford; Børge G. Nordestgaard; Sune F. Nielsen; Hermann Brenner; C. Maier; Jeri Kim; Esther M. John; Manuel R. Teixeira; Kim De Ruyck; Lisa F. Newcomb; Davor Lessel; Radka Kaneva; Nawaid Usmani; Frank Claessens; Paul A. Townsend; Jose Esteban Castelao; Monique J. Roobol; Florence Menegaux; K. T. Khaw; Lisa Cannon-Albright; Hardev S. Pandha; Stephen N. Thibodeau; David J. Hunter; Peter Kraft; WJ Blot; Elio Riboli; VA Million Veteran Program; Sumitra Muralidhar; Jennifer Moser; Jennifer E. Deen; Philip S. Tsao; J. Michael Gaziano; Adriana Hung; Dave Oslin; Deepak Voora; Jessica V. Brewer; Mary T. Brophy; Kelly Cho; Lori Churby; Jacob T. Kean; Saiju Pyarajan; Robert Ringer; Luis Selva; Shahpoor Alex Shayan; Brady Stephens; Stacey B. Whitbourne; Tyler M Seibert

doi:10.1038/s43018-025-01103-0

Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study

Jason L. Vassy(Harvard University), Anna Dornisch(University of California San Diego), Roshan Karunamuni(University of California San Diego), Michael Gatzen(Broad Institute), Christopher J. Kachulis(Broad Institute), Niall J. Lennon(Broad Institute), Charles A. Brunette(Harvard University), Morgan E. Danowski(VA Boston Healthcare System), Richard L. Hauger(University of California San Diego), Isla P. Garraway(University of California, Los Angeles), Adam S. Kibel(Brigham and Women's Hospital), Kyung M. Lee(VA Salt Lake City Healthcare System), Julie A. Lynch(VA Salt Lake City Healthcare System), Kara N. Maxwell(Philadelphia VA Medical Center), Dmitry Ratner(VA Boston Healthcare System), Brent S. Rose(University of California San Diego), Craig C. Teerlink(University of Utah), George J. Xu(University of California San Diego), Sean E Hofherr(Broad Institute), Katherine A Lafferty(Broad Institute), Katie Larkin(Broad Institute), Edyta Małolepsza(Broad Institute), Candace Patterson(Broad Institute), Diana M. Toledo(Broad Institute), Jenny L. Donovan(University of Bristol), Freddie C. Hamdy(University of Oxford), Richard M. Martin(University Hospitals Bristol NHS Foundation Trust), David Edgar Neal(University of Cambridge), E. C. Turner(University of Bristol), Ole A Andreassen(Oslo University Hospital), Anders M. Dale(Oslo University Hospital), Ian G. Mills(University of Oxford), Aswin Abraham(University of Alberta), Jyotsna Batra(Bond University), Judith Clements(Prostate Cancer Foundation of Australia), Olivier Cussenot(Sorbonne Université), C. Cybulski(International Hereditary Cancer Center), Rosalind A. Eeles(Royal Marsden NHS Foundation Trust), Jay H. Fowke(University of Tennessee Health Science Center), Eli Marie Grindedal(Oslo University Hospital), Henrik Gronberg(Karolinska Institutet), Rob Hamilton(University of Toronto), Jasmine Lim(University of Malaya), Yong-Jie Lu(Queen Mary University of London), Robert J. MacInnis(The University of Melbourne), C. Maier(Universität Ulm), Mucci La(Harvard University), Multigner Luc(Inserm), Susan L. Neuhausen(City of Hope), Sune F. Nielsen(University of Copenhagen), Marie-Élise Parent(Institut National de la Recherche Scientifique), Jong Y. Park(Moffitt Cancer Center), György Petrovics(Uniformed Services University of the Health Sciences), Anna Plym(Harvard University), Azad Hassan Abdul Razack(University of Malaya), B ROSENSTEIN(Icahn School of Medicine at Mount Sinai), Johanna Schleutker(University of Turku), Karina Dalsgaard Sørensen(Aarhus University), Paul A. Townsend(Manchester Academic Health Science Centre), Ruth C. Travis(University of Oxford), A. I. Vega(Centre for Biomedical Network Research on Rare Diseases), Catharine M. L. West(Manchester Academic Health Science Centre), Fredrik Wiklund(Karolinska Institutet), Wei Zheng(Vanderbilt University Medical Center), Rosalind A. Eeles(Royal Marsden NHS Foundation Trust), Elizabeth K. Bancroft(Royal Marsden NHS Foundation Trust), Eva McGrowder(Institute of Cancer Research), Z. Kote-Jarai(Institute of Cancer Research), Mark N. Brook(Institute of Cancer Research), Elizabeth C. Page(Institute of Cancer Research), Jana McHugh(Institute of Cancer Research), Holly Ni Raghallaigh(Institute of Cancer Research), Denzil Robert James(Royal Marsden NHS Foundation Trust), Pardeep Kumar(Royal Marsden NHS Foundation Trust), Steve Hazell(Royal Marsden NHS Foundation Trust), Aslam Sohaib(Royal Marsden NHS Foundation Trust), Alexander Edwin Teixeira Dias(Institute of Cancer Research), Christos Mikropoulos(Institute of Cancer Research), Netty Kinsella(Royal Marsden NHS Foundation Trust), Declan Cahill(Royal Marsden NHS Foundation Trust), Elizabeth K. Bancroft(Royal Marsden NHS Foundation Trust), Elizabeth C. Page(Institute of Cancer Research), D. Gareth Evans(Center for Genomic Science), Geoffrey J. Lindeman(The University of Melbourne), Paul James(Walter and Eliza Hall Institute of Medical Research), Lucy Side(Princess Anne Hospital), Karina Rønlund(Vejle Sygehus), Brian T. Helfand(NorthShore University HealthSystem), C. Cybulski(International Hereditary Cancer Center), Kai‐Ren Ong(Birmingham Women's Hospital), Monica Salinas(Institut d'Investigació Biomédica de Bellvitge), Jackie Cook(Sheffield Children's NHS Foundation Trust), Kara N. Maxwell(Philadelphia VA Medical Center), Manuel R. Teixeira(Universidade do Porto), Rosemarie Davidson(Queen Elizabeth University Hospital), A. Liljegren(Karolinska University Hospital), Ashraf Azzabi(Newcastle upon Tyne Hospital), Marc Tischkowitz(Cambridge University Hospitals NHS Foundation Trust), Ruth Cleaver(Royal Devon and Exeter Hospital), Julian Barwell(University of Leicester), Neil K. Aaronson(The Netherlands Cancer Institute), Audrey Ardern-Jones(Royal Marsden NHS Foundation Trust), Chris H. Bangma(Erasmus MC), Elena Castro(Hospital Universitario 12 De Octubre), David Dearnaley(Institute of Cancer Research), Diana Eccles(Princess Anne Hospital), Alison Falconer(Imperial College Healthcare NHS Trust), Henrik Gronberg(Karolinska Institutet), Freddie C. Hamdy(University of Oxford), Vincent Khoo(Royal Marsden NHS Foundation Trust), H. Lilja(Memorial Sloan Kettering Cancer Center), Jan Lubiński(International Hereditary Cancer Center), Christos Mikropoulos(Institute of Cancer Research), A. Mitra(University College London Hospitals NHS Foundation Trust), Judith Offman(Queen Mary University of London), Rennert Gad(Technion – Israel Institute of Technology), Mohnish Suri(Nottingham City Hospital), Christopher A. Haiman(University of Southern California), Z. Kote-Jarai(Institute of Cancer Research), Fredrick R. Schumacher(University Hospitals Seidman Cancer Center), S. Benlloch(Institute of Cancer Research), Ali Amin Al Olama(University of Cambridge), Ken Muir(Manchester Academic Health Science Centre), S. I. Berndt(National Cancer Institute), David V. Conti(University of Southern California), Fredrik Wiklund(Karolinska Institutet), Stephen Chanock(National Cancer Institute), Ying Wang(American Cancer Society), Catherine M. Tangen(Fred Hutch Cancer Center), Henrik Gronberg(Karolinska Institutet), Nora Pashayan(Department of Public Health), Demetrius Albanes(National Cancer Institute), Stephanie J. Weinstein(National Cancer Institute), Alicja Wolk(Karolinska Institutet), Catharine M. L. West(Manchester Academic Health Science Centre), Géraldine Cancel-Tassin(Sorbonne Université), Stella Koutros(National Cancer Institute), David Edgar Neal(University of Cambridge), Freddie C. Hamdy(University of Oxford), Rob Hamilton(University of Toronto), SA Ingles(University of Southern California), B ROSENSTEIN(Icahn School of Medicine at Mount Sinai), Yongjie Lu(Queen Mary University of London), Graham G. Giles(The University of Melbourne), Robert J. MacInnis(The University of Melbourne), Adam S. Kibel(Brigham and Women's Hospital), M Kogevinas(Universitat Pompeu Fabra), Kathryn L. Penney(Brigham and Women's Hospital), Janet L. Stanford(University of Washington), Børge G. Nordestgaard(University of Copenhagen), Sune F. Nielsen(University of Copenhagen), Hermann Brenner(German Cancer Research Center), C. Maier(Universität Ulm), Jeri Kim(The University of Texas MD Anderson Cancer Center), Esther M. John(Stanford Medicine), Manuel R. Teixeira(Universidade do Porto), Kim De Ruyck(Ghent University), Lisa F. Newcomb(University of Washington), Davor Lessel(University Hospital Regensburg), Radka Kaneva(Medical University of Sofia), Nawaid Usmani(University of Alberta), Frank Claessens(KU Leuven), Paul A. Townsend(Manchester Academic Health Science Centre), Jose Esteban Castelao(University Hospital Complex Of Vigo), Monique J. Roobol(Erasmus MC Cancer Institute), Florence Menegaux(Inserm), K. T. Khaw(University of Cambridge), Lisa Cannon-Albright(University of Utah), Hardev S. Pandha(University of Surrey), Stephen N. Thibodeau(Mayo Clinic in Arizona), David J. Hunter(University of Oxford), Peter Kraft, WJ Blot(International Epidemiology Institute), Elio Riboli(Imperial College London), VA Million Veteran Program, Sumitra Muralidhar(United States Department of Veterans Affairs), Jennifer Moser(United States Department of Veterans Affairs), Jennifer E. Deen(United States Department of Veterans Affairs), Philip S. Tsao(VA Palo Alto Health Care System), J. Michael Gaziano(VA Boston Healthcare System), Adriana Hung(VA Tennessee Valley Healthcare System), Dave Oslin(Philadelphia VA Medical Center), Deepak Voora(Durham VA Medical Center), Jessica V. Brewer(VA Boston Healthcare System), Mary T. Brophy(VA Boston Healthcare System), Kelly Cho(VA Boston Healthcare System), Lori Churby(VA Palo Alto Health Care System), Jacob T. Kean(VA Salt Lake City Healthcare System), Saiju Pyarajan(VA Boston Healthcare System), Robert Ringer(New Mexico VA Health Care System), Luis Selva(VA Boston Healthcare System), Shahpoor Alex Shayan(VA Boston Healthcare System), Brady Stephens(Canandaigua VA Medical Center), Stacey B. Whitbourne(VA Boston Healthcare System), Tyler M Seibert(UC San Diego Health System)

Nature Cancer

January 26, 2026

10.1038/s43018-025-01103-0

Cited by 1Open Access

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