Endotoxin in Health and Disease

Abstract

Endotoxin - historical perspectives lipopolysaccharide and the permeability of the bacterial outer membrane lypopolysacharide phase variation in haemophilus and neisseria antigenic mimicry in neisseris spp antibiotic-induced endotoxin release - important parameters dictating responses complement-mediated lipopolysaccharide release chemical structure of lipid A - recent advances in structural analysis of biologically active molecules chemical structure of the core region of lipopolysaccharides the chemistry of O-polysacharide chains in bacterial lipopolysaccharides the chemistry and biology of lipooligosacharides - the endotoxins of bacteria of the respiratory and genital mucosae a biophysical view on the function and activity of endotoxins lipopolysaccharide preparations in aqueous media -implications for solution versus suspension chlamydia lipopolysaccharides chemical synthesis of lipid A chemical synthesis of core structures microbial pathways of lipid A biosynthesis biosynthesis and genetics of lipopolysaccharides core genetics and biosynthesis of lipopolysacchrides O-antigens lipopolysaccharide-binding protein bactericidal/permeability-increasing protein, P15s and phospholipases A2, endogenous antibiotics in host defense against bacterial infection interactions of lipopolysacharides and lipoproteins effects of human haemoglobin on bacterial endotoxin in vitro and in vivo LPS/lipid A binding synthetic peptides interaction of lipid A and lipopolysaccharide with human serum albumin endothelial cell activation by lipopolysaccharide - role of soluble CD14 scavenger receptor and lipopolysaccharide - the role of platelet-activating factor CD14, an innate immune receptor for various bacterial cell wall components the role of MAP kinases, phosphatidylinositol 3-kinase and ceramide in LPS-induced signalling in macrophages endotoxin effects on synthesis of phosphatidic acid and phosphatidic acid-derived diacylglyceride species. (Part contents).