Multicentric Giant Lymph Node Hyperplasia

Abstract

Gaba, Arthur R., Stein, Richard S., Sweet, Donald L., and Variakojis, Daina: Multicentric giant lymph node hyperplasia. Am J Clin Pathol 69: 86–90, 1978. A patient with retroperitoneal and axillary lymphadenopathy and splenomegaly was demonstrated histologically to have the hyaline vascular type of giant lymph node hyperplasia, with plasma cell infiltrates in each region. The abdominal lesions were not surgically resectable and did not respond to radiotherapy. The clinical findings included polyclonal gammopathy, high cold agglutinin titers, neuropathy, and bilateral papilledema. All of these abnormalities have persisted three years since the initial diagnosis.