Regioselective Cross-Couplings of Coumarins and Flavones with Ethers via C(sp<sup>3</sup>)–H Functionalization
Ben Niu(Jiangsu University), Wannian Zhao(Jiangsu University), Yingcai Ding(Jiangsu University), Zhaogang Bian(Jiangsu University), Charles U. Pittman(Mississippi State University), Aihua Zhou(Jiangsu University), Haibo Ge(Indiana University – Purdue University Indianapolis)
Cited by 93
Abstract
Coumarin and flavone derivatives are highly valuable molecules in drug discovery. Here, two new regioselective cross-dehydrogenation couplings of coumarins and flavones with different ethers via C(sp(3))-H functionalization processes were developed, generating new ether-substituted derivatives not previously reported. These reactions proceeded well via radical mechanisms and provided the corresponding products in good yields.
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