Handbook of Drug Metabolism

Abstract

FUNDAMENTAL ASPECTS OF DRUG METABOLISM Pharmacokinetics of Drug Metabolites, P.C. Smith Oxidative Metabolic Bioactivation of Xenobiotics, S. Mabic, K. Castagnoli, and N. Castagnoli, Jr. Morphofunctional Aspects of the Hepatic Architecture: Functional and Subcellular Correlates, F.A. de la Iglesia, D.G. Robertson, and J.R. Haskins The Cytochrome P450 Oxidative System, P.R. Ortiz de Montellano Transformation Enzymes: Oxidative Non-P450, A.E. Rettie and M.B. Fisher Transformation Reactions: Glucuronidation, B. Burchell FACTORS AFFECTING DRUG METABOLISM Pharmacogenetics, A.K. Daly Inhibition of Drug Metabolizing Enzymes: Molecular and Biochemical Aspects, F.P. Guengerich Metabolic Drug Interactions, W.D. Hooper Induction of Human Drug-Metabolizing Enzymes: Mechanisms and Implications, M.J.J. Ronis and M. Ingelman-Sundberg Sites of Metabolism: Lung, G.S. Yost TECHNOLOGIES Applications of Heterologous Expressed and Purified Human Drug-Metabolizing Enzymes: An Industrial Perspective, A.D. Rodrigues In Vivo and In Vitro Recombinant DNA Technology as a Powerful Tool in Drug Development, T. Friedberg, C.J. Henderson, M.P. Pritchard, and C.R. Wolf In Vitro Metabolism: Subcellular Fractions, S. Ekins, J. Maenpaa, and S.A. Wrighton In Vitro Metabolism: Hepatocytes, M.W. Sinz The Isolated Perfused Liver as a Tool in Drug Metabolism Studies, M. Kukan Metabolic Models of Cytotoxicity, M. Pirmohamed and B.K. Park In Vitro Metabolism: FMO and Related Oxygenations, J.R. Cashman Applications of Caco-2 Cells in Drug Discovery and Development, S. Yee and W.W. Day The Role of Nuclear Magnetic Resonance Spectroscopy in Drug Metabolism, I.D. Wilson, J.K. Nicholson, and J.C. Lindon METABOLISM IN DRUG DISCOVERY AND DEVELOPMENT Preclinical Drug Metabolism Studies and Strategies, P.B. Inskeep and W.W. Day Clinical Drug Metabolism Studies, W.F. Pool