Opposing functions of distinct regulatory T cell subsets in colorectal cancer
Xiao Huang(Memorial Sloan Kettering Cancer Center), Dan Feng(Icahn School of Medicine at Mount Sinai), Sneha Mitra(Memorial Sloan Kettering Cancer Center), Emma S. Andretta(Memorial Sloan Kettering Cancer Center), Nima Hooshdaran(Memorial Sloan Kettering Cancer Center), Aazam P. Ghelani(Cornell University), Eric Y. Wang(Cornell University), Joe N. Frost(Memorial Sloan Kettering Cancer Center), Victoria R Lawless(Memorial Sloan Kettering Cancer Center), Aparna Vancheswaran(Memorial Sloan Kettering Cancer Center), Qingwen Jiang(Memorial Sloan Kettering Cancer Center), Cheryl Mai(Cornell University), Karuna Ganesh(Memorial Sloan Kettering Cancer Center), Christina S. Leslie(Memorial Sloan Kettering Cancer Center), Alexander Y. Rudensky(Memorial Sloan Kettering Cancer Center)
Cited by 1Open Access
Abstract
Treg cells exhibited opposite enrichment patterns in adjacent normal colon tissues and tumors. Transcriptionally similar Treg subsets were observed across different human barrier tissue tumors. This functional dichotomy between Treg subsets may enable selective targeting of the pro-tumoral subset while preserving its anti-tumoral counterpart in CRC and other barrier tissue cancers.
Related Papers
No related papers found
Powered by citation graph analysis