Sphingomyelin Synthase 2 Deletion Mitigates Oxidative Stress-Induced NF-κB Activation via Lipid Metabolic Reprogramming in Dry Eye Disease

Yiteng Lu(Eye & ENT Hospital of Fudan University), Jiaxu Hong(Shanghai Eye Disease Prevention & Treatment Center), Qingye Zhang(Huazhong Agricultural University), Xichen Wan(Fudan University), Mingrui Cheng(Fudan University), Yuqing Wu(Henan Academy of Agricultural Sciences), Xujiao Zhou(Fudan University), Runhan Shi(Fudan University), Han Ye(Beijing University of Posts and Telecommunications), Xingyu Zhu(Shandong Provincial Hospital), Yirou Zhang(Eye & ENT Hospital of Fudan University), Jingyuan Wang(Hebei Medical University), Qihua Le(Fudan University)
Investigative Ophthalmology & Visual Science
December 5, 2025
10.1167/iovs.66.15.22
Cited by 2

Related Papers

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice
|Nature Biotechnology|2021|186
Therapeutic Nanoparticles from Grape Seed for Modulating Oxidative Stress
|Small|2021|109
Membrane Fusion‐Mediated Loading of Therapeutic siRNA into Exosome for Tissue‐Specific Application
|Advanced Materials|2024|88
Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma
|Journal of Neuroscience|2018|78
Customizable virus-like particles deliver CRISPR–Cas9 ribonucleoprotein for effective ocular neovascular and Huntington’s disease gene therapy
|Nature Nanotechnology|2025|75