Fusion-specific regulation of polyamine synthesis sensitizes to BCL-XL inhibition in TCF3::PBX1+ B-ALL

James Kim(University Children's Hospital Zurich), Jean‐Pierre Bourquin(University Children's Hospital Zurich), Bartimée Galvan(University Children's Hospital Zurich), S Ulrich(University Children's Hospital Zurich), Sarah Cherkaoui(University Children's Hospital Zurich), Chengkang Li(University Children's Hospital Zurich), Raphael J. Morscher(University Children's Hospital Zurich), Caroline Mussak(University Children's Hospital Zurich), Shannon Mezger(University Children's Hospital Zurich), Beat Bornhäuser(University Children's Hospital Zurich)
Blood
November 3, 2025
10.1182/blood-2025-3260
Cited by 0

Related Papers

Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
|Cell Metabolism|2016|440
Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group
|Blood|2009|347
Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
|Journal of Clinical Investigation|2010|311
<i>IKZF1</i><sup>plus</sup>Defines a New Minimal Residual Disease–Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia
|Journal of Clinical Oncology|2018|304
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7
|Science Advances|2019|274