First-line serplulimab plus chemotherapy with or without HLX04 versus chemotherapy in locally advanced or metastatic non-squamous non-small-cell lung cancer (ASTRUM-002): a randomised, double-blind, multicentre phase 3 trial

Lin Wang; Xuezhi Hao; Yanrong Hao; Yanping Hu; Chun Chen; Bi Chen; Yunchao Huang; Aimin Zang; Yan Wang; Zhendong Chen; Wu Zhuang; Jinsheng Shi; Xiubao Ren; Ligong Nie; Guohua Yu; Feng Luo; Yimin Mao; Xiang Wang; Baolan Li; Yuansong Bai; Jianhua Shi; Hongyan Ni; Haoyu Yu; Jing Li; Qingyu Wang; Junwu Zhu; Yuankai Shi; Kejing Ying; Guoping Sun; Jinsheng Wu; Chuan Jin; Lin H. Lin; Xingya Li; Hongmei Sun; Zhengguo Li; Liangming Zhang; Xicheng Wang; Xueli Yuan; Tangfeng Lv; Yinghua Ji; Jian Fang; Guangyu An; Yueyin Pan; Lin Wu; Jiuwei Cui; Wei Zhang; Jianying Zhou; Xiaohong Wu; Qingshan Li; Jun Liang; Hui Luo; Huiwen Ma; Bangwei Cao; Jingchang Li; Rui Meng; Xi Chen; Fen Wang; Y Li; Yiping Zhang; Xiaoping Huang; Rui Ma; Zhiyong Ma; Yan Tan; Wen Li; Youlun Li; Na Li; Dongji Chen; Hui Zhao; Haixin Huang; Zhongyao Jia; Jun Chen; Jianhua Chang; Meili Sun; Youxin Ji; Zhitu Zhu; Aihong Zhong; Yarong Li; Liyan Jiang; Dongqing Lv; Mengzhao Wang; Wei Zhang; Ming Fan; Manxiang Li; Zhenping Wen; Haichuan Su; Diansheng Zhong; Min Ye

doi:10.1016/s2213-2600(25)00263-2

First-line serplulimab plus chemotherapy with or without HLX04 versus chemotherapy in locally advanced or metastatic non-squamous non-small-cell lung cancer (ASTRUM-002): a randomised, double-blind, multicentre phase 3 trial

Lin Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Xuezhi Hao(Chinese Academy of Medical Sciences & Peking Union Medical College), Yanrong Hao(The People's Hospital of Guangxi Zhuang Autonomous Region), Yanping Hu(Hubei Cancer Hospital), Chun Chen(Fujian Medical University), Bi Chen(Xuzhou Medical College), Yunchao Huang, Aimin Zang(Affiliated Hospital of Hebei University), Yan Wang(Harbin Medical University), Zhendong Chen(Anhui Medical University), Wu Zhuang(Fujian Provincial Cancer Hospital), Jinsheng Shi(People's Hospital of Cangzhou), Xiubao Ren(Tianjin Medical University Cancer Institute and Hospital), Ligong Nie(Peking University), Guohua Yu(Weifang People's Hospital), Feng Luo(Sichuan University), Yimin Mao(First Affiliated Hospital of Henan University of Science and Technology), Xiang Wang(Xuzhou Central Hospital), Baolan Li(Capital Medical University), Yuansong Bai(Union Hospital), Jianhua Shi(People's Hospital of Cangzhou), Hongyan Ni(Viva Biotech (China)), Haoyu Yu(Viva Biotech (China)), Jing Li(Viva Biotech (China)), Qingyu Wang(Viva Biotech (China)), Junwu Zhu(Viva Biotech (China)), Yuankai Shi(Chinese Academy of Medical Sciences & Peking Union Medical College), Kejing Ying, Guoping Sun, Jinsheng Wu, Chuan Jin, Lin H. Lin, Xingya Li, Hongmei Sun, Zhengguo Li, Liangming Zhang, Xicheng Wang(Xuzhou Central Hospital), Xueli Yuan, Tangfeng Lv, Yinghua Ji, Jian Fang, Guangyu An, Yueyin Pan, Lin Wu, Jiuwei Cui, Wei Zhang, Jianying Zhou, Xiaohong Wu, Qingshan Li, Jun Liang, Hui Luo, Huiwen Ma, Bangwei Cao, Jingchang Li(Viva Biotech (China)), Rui Meng, Xi Chen, Fen Wang, Y Li, Yiping Zhang, Xiaoping Huang, Rui Ma, Zhiyong Ma, Yan Tan, Wen Li, Youlun Li, Na Li, Dongji Chen, Hui Zhao, Haixin Huang, Zhongyao Jia, Jun Chen, Jianhua Chang, Meili Sun, Youxin Ji, Zhitu Zhu, Aihong Zhong, Yarong Li, Liyan Jiang, Dongqing Lv, Mengzhao Wang, Wei Zhang, Ming Fan, Manxiang Li, Zhenping Wen, Haichuan Su, Diansheng Zhong, Min Ye

The Lancet Respiratory Medicine

December 4, 2025

10.1016/s2213-2600(25)00263-2

Cited by 3

Abstract

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