Therapeutic approaches in adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of current evidence

Jakob Stögbauer(Saarland University), Victoria Schegerer(Saarland University), Clemens Klein(Saarland University), Marc Pawlitzki(Düsseldorf University Hospital), Sven G. Meuth(Düsseldorf University Hospital), Orhan Aktaş(Düsseldorf University Hospital), Sergiu Groppa(Saarland University), Mathias Fousse(Saarland University)
Autoimmunity Reviews
December 3, 2025
Cited by 1Open Access
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Abstract

Recent years have seen a considerable increase in knowledge pertaining to Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD). Nevertheless, a noteworthy degree of uncertainty remains within the neurological community, primarily due to the often highly heterogeneous nature of the disease and the absence of approved long-term treatment options. In this article, we undertake a comprehensive review of the various treatment strategies and drug options available for the pharmacological treatment of acute attacks and relapses in MOGAD.


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