Application of a bioengineered intestinal epithelium for drug permeability and metabolism studies
Elisabeth Gill(Roche (Switzerland)), Stephanie Muenchau Schoepp(Roche (Switzerland)), Sina Simon(Roche (Switzerland)), Marius F. Harter(Roche (Switzerland)), Mikhail Nikolaev(Roche (Switzerland)), Iago Pereiro(Roche (Switzerland)), Inês Silva(Roche (Switzerland)), Rubén López-Sandoval(Roche (Switzerland)), Marco Berrera(Roche (Switzerland)), Tony Kam‐Thong(Roche (Switzerland)), Marco Michalski(Roche (Switzerland)), Michael Zaayman(Roche (Switzerland)), Julien Aubert(Roche (Switzerland)), Irineja Cubela(Roche (Switzerland)), Janneke Keemink(Roche (Switzerland)), Cordula Stillhart(Roche (Switzerland)), Michael Hofmann(Roche (Switzerland)), Stephen Fowler(Roche (Switzerland)), J. Gray Camp(Roche (Switzerland)), Nicolò Milani(Roche (Switzerland)), Nikolche Gjorevski(Roche (Switzerland))
Cited by 2Open Access
Abstract
Gill, Muenchau et al. demonstrated the presence of key drug transporters and metabolic enzymes in an engineered intestinal barrier model, and combined the system with in silico modeling to simultaneously capture drug permeability and metabolism.
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