A preventive care strategy to reduce moderate or severe acute kidney injury after major surgery (BigpAK-2); a multinational, randomised clinical trial

Alexander Zarbock(University Hospital Münster), Christian Arndt(Philipps University of Marburg), Adam Glass(Queen's University Belfast), John A. Kellum(University of Pittsburgh), Tim Rahmel(Universitätsklinikum Knappschaftskrankenhaus Bochum), Nuttha Lumlertgul(Chulalongkorn University), Christian Bode(University Hospital Bonn), Savino Spadaro(University of Ferrara), Javier Ripollés‐Melchor(Universidad Complutense de Madrid), Antoine Schneider(Centre Hospitalier Universitaire Vaudois), Lucie Aupetitgendre(University of Clermont Auvergne), Lui G. Forni(University of Pittsburgh), James Gossage, Jan Gerrit Haaker(St. Franziskus Hospital), Céline Monard(Hospices Civils de Lyon), Silvia De Rosa(University of Trento), Marlies Ostermann(St Thomas' Hospital), Diego Parise Roux(Hospital Universitario Ramón y Cajal), Emmanuel Futier(Centre National de la Recherche Scientifique), Irene Romero Bhathal(Hospital Universitario 12 De Octubre), Mahan Sadjadi(University Hospital Münster), Mona Jung-König(Heidelberg University), Christian Putensen(University Hospital Bonn), Melanie Meersch(University Hospital Münster), Peter Rosenberger(University of Tübingen), Raquel García-Álvarez(Hospital Universitario 12 De Octubre), Stefano Romagnoli(University of Florence), Carola Wempe(University Hospital Münster), E Martin(Philipps University of Marburg), Lennart Wild, Alice Bernard(University of Tübingen)

The Lancet

November 14, 2025

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