Discovery of XRF-1021, a 2,4-disubstituted-5-fluoropyrimidine derivative as a homeodomain-interacting protein kinase 2 inhibitor for the treatment of chronic kidney disease

Xinlan Hu(Central South University), Qianbin Li(Central South University), Yan Wu(Shanghai Public Health Clinical Center), Hanyi Ouyang(Central South University), Li Gong(Central South University), Songkai Wang(Central South University), Ling Huang(Southern University of Science and Technology), Yuanyuan Han(Western University), Zhangzhe Peng(Central South University), Jiawei Cheng(Central South University), Yuanyuan Cao(Chinese Academy of Sciences), Qiongjing Yuan(Central South University), Zhuo Chen(Northeast Agricultural University), Yan Zhang(East China University of Science and Technology), Lijian Tao(Central South University), Jianhua Zeng(Shanghai East Hospital), Jie Meng(Central South University), Songsen Fu(Hunan University), Yiwei Xiong(Central South University), Sijue Zou(Central South University), Xin He(Central South University)
European Journal of Medicinal Chemistry
November 7, 2025
Cited by 1


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