A single phospho-LCK flow-cytometry readout predicts dasatinib sensitivity in paediatric T-cell acute lymphoblastic leukaemia

Alistair A. Poll(Newcastle University), Frederik W. van Delft(Newcastle University), Andreas E. Kulozik(Heidelberg University), Jean‐Pierre Bourquin(University Children's Hospital Zurich), Kerstin K. Rauwolf(University Children's Hospital Zurich), Yuzhe Shi(Columbia University Irving Medical Center), Julie Irving(Newcastle University), Beat Bornhäuser(University Children's Hospital Zurich)

bioRxiv (Cold Spring Harbor Laboratory)

November 6, 2025

10.1101/2025.11.04.684929

Cited by 0

Related Papers

Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

|Blood|2009|347

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

|Journal of Clinical Investigation|2010|311

<i>IKZF1</i><sup>plus</sup>Defines a New Minimal Residual Disease–Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

|Journal of Clinical Oncology|2018|304

Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia

|Blood|2006|293

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

|Science Advances|2019|274