Optimizing efficacy and safety of T cell bispecific antibodies: the interdependence of CD3 and tumor antigen binder affinities in FOLR1 and CEACAM5 2 + 1 TCBs

Omar Abdelmotaleb(Roche (Switzerland)), Christian Klein(Roche (Switzerland)), Katharina Essig(Roche (Switzerland)), Stephan Märsch(Roche (Switzerland)), Thomas Höfer(Heidelberg University), Anna Maria Giusti(University of Illinois Urbana-Champaign), Sara Colombetti(Roche (Switzerland)), Alex Odermatt(University of Basel), Anne Freimoser–Grundschober(Roche (Switzerland)), Inja Waldhauer(Roche (Switzerland)), Linda Steinacher(Roche (Switzerland)), Ali Bransi(Roche (Switzerland)), Peter Brünker(Roche (Switzerland)), Johannes Sam(Roche (Switzerland)), Tijana Nikić(Roche (Switzerland)), Christian Gassner(Roche (Switzerland)), Anneliese Schneider(Roche (Switzerland)), Martin Lechmann(Roche (Switzerland))
mAbs
November 6, 2025
Cited by 2


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