Figure_S11 from Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors
Elliott J. Brea, Simon Baldacci, Neil Savage, Francesco Facchinetti, Conor Hinchey, Sachiv Chakravarti, Alexis Mottram, Kenneth Ngo, Ha Vo, Brittaney A. Leeper, Bishma Tuladhar, Suthakar Ganapathy, Elena V. Ivanova, Aisha Saldanha, Marie-Anaïs Locquet, Abdulmajeed Salamah, Malcolm Holterhus, Evelyn B. Mesler, Martina De Vizio, Carla Stornante, Marco Campisi, Navin R. Mahadevan, Tran C. Thai, Timothy J. Haggerty, Zehua Li, Cui Nie, Changjing Deng, Xiaoxiao Wang, Louis L. Liu, Thanh U. Barbie, Prafulla C. Gokhale, Cloud P. Paweletz, Anusuya Ramasubramanian, Pasi A. Jänne, David A. Barbie, Eric L. Smith
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Abstract
<p>Figure S11. In vitro live-cell imaging of PC9 WT treated with various TROP2 CAR constructs. In vitro activity in live-cell imaging assay of TROP2 CARs against PC9 WT. PC9 was transduced with GFP and live-cell imaging performed on Incucyte with counting of green objects. Cytotoxicity index is green cell object count relative to t = 0 when CARs were applied at E:T of 0.25:1. Data are representative of multiple independent experiments with different donors.</p>
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