New Delhi metallo-β-lactamase-producing Acinetobacter baumannii in the USA from October, 2013, to March, 2022: a retrospective molecular epidemiological analysis

Magdalena Medrzycki(Centers for Disease Control and Prevention), Richard A. Stanton(Centers for Disease Control and Prevention), Danielle A. Rankin(Centers for Disease Control and Prevention), Sam Horwich-Scholefield(California Department of Public Health), Arif Mahmud(Texas Department of State Health Services), Tyler Maruca(Maryland Department of Health), Sarah Brister(Illinois Department of Public Health), Lian Hsiao(California Department of Public Health), Elisabeth Vaeth(Maryland Department of Health), Michelle Therrien(Tennessee Department of Health), Erin L. Young(Utah Department of Health), Kelly F. Oakeson(Utah Department of Health), Farhana Haque(Baltimore City Health Department), Lindsay Neff(University of Utah), Alison Laufer Halpin(Centers for Disease Control and Prevention), Sarah Sabour(Centers for Disease Control and Prevention), J. Huang(Centers for Disease Control and Prevention), Stephen LaVoie(Centers for Disease Control and Prevention), Maroya Spalding Walters(Centers for Disease Control and Prevention)
The Lancet Microbe
October 25, 2025
10.1016/j.lanmic.2025.101201
Cited by 0Open Access
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Abstract

BACKGROUND: Most US carbapenem-resistant Acinetobacter baumannii (CRAB) isolates harbour carbapenem-hydrolysing class D β-lactamases. Other carbapenemases, such as New Delhi metallo-β-lactamase (NDM), are uncommon but emerging. We describe the epidemiology of NDM-producing CRAB reported to the US Centers for Disease Control and Prevention (CDC). METHODS: ]) and core genome MLST. To understand the potential origins of NDM-CRAB in the USA, we compared sequences of cases to US CRAB without NDM and to NDM-CRAB from non-US locations. FINDINGS: 1697) were closely related to international NDM-CRAB isolates. INTERPRETATION: We identified regionally distinct NDM-CRAB strains, suggesting localised transmission in the USA. Some NDM-CRAB strains in the USA are closely related to strains identified outside the USA, suggesting that spread followed importation. FUNDING: None.

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