CSF1R inhibitors pexidartinib and sotuletinib induce rapid glial ablation despite their limited brain penetrability

Olaf van Tellingen(Dutch Cancer Society), Laura E. Kuil(The Netherlands Cancer Institute), Sanne B. Schagen(Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital), Artur M Burylo(The Netherlands Cancer Institute), Caroline van Heijningen(The Netherlands Cancer Institute), Efi Tsouri(The Netherlands Cancer Institute), Yoran M Leter(The Netherlands Cancer Institute), Zoey J Tolboom(The Netherlands Cancer Institute), Mark C. de Gooijer(Manchester Academic Health Science Centre)
bioRxiv (Cold Spring Harbor Laboratory)
October 13, 2025
Cited by 0


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