A human pan-disease blood atlas of the circulating proteome
María Bueno Álvez(Science for Life Laboratory), Sofia Bergström(Science for Life Laboratory), Josefin Kenrick(Science for Life Laboratory), Emil Johansson(Science for Life Laboratory), Mikael Åberg(Uppsala University), Murat Akyıldız(Koç University), Özlem Altay(Science for Life Laboratory), Hilda Sköld(Science for Life Laboratory), Κωνσταντίνος Αντωνόπουλος(Science for Life Laboratory), Emmanouil Apostolakis(Science for Life Laboratory), Yasin Hasan Balcıoğlu(Bakırköy Psychiatric Hospital), Anna Bergström(Karolinska Institutet), Göran Bergström(Sahlgrenska University Hospital), Sophia Björkander(Karolinska Institutet), Suzanne Egyhazi Brage(Karolinska Institutet), Petter Brodin(Hammersmith Hospital), Lynn M. Butler(Science for Life Laboratory), Sara Cajander(Örebro University), Hanna Danielsson(Karolinska Institutet), Murat Dayangaç(Istanbul Medipol University), Gizem Dinler Doğanay(Istanbul Technical University), Levent Doğanay(Bahçeşehir University), Gunilla Enblad(Uppsala University), Malin Enblad(Uppsala University), Linn Fagerberg(Science for Life Laboratory), Sara Falck‐Jones(Karolinska University Hospital), Anna Färnert(Karolinska University Hospital), Mattias Forsberg(Science for Life Laboratory), Laura González‐Aguilera(Karolinska Institutet), Anders Gummesson(Sahlgrenska University Hospital), Karin Gunnarsson(Karolinska University Hospital), Iva Gunnarsson(Karolinska University Hospital), Ulf Gyllensten(Uppsala University), Göran Hesselager(Uppsala University), Andreas Hober(Science for Life Laboratory), Martin Höglund(Uppsala University), Marie Holmqvist(Karolinska University Hospital), Begum Horuluoglu(Karolinska University Hospital), Rebecka Hultgren(Karolinska University Hospital), María Jesús Iglesias(Science for Life Laboratory), Helena Janols(Uppsala University), Fredric Johansson(Science for Life Laboratory), Anette Johnsson(Karolinska Institutet), Lars Klareskog(Karolinska Institutet), David Kotol(Science for Life Laboratory), Inger Kull(Karolinska Institutet), Marika Kvarnström(Karolinska Institutet), Maximilian Julius Lautenbach(Karolinska University Hospital), Ulrika Liljedahl(Uppsala University), Henrik Lindman(Uppsala University), Cecilia Lindskog(Uppsala University), Miklós Lipcsey(Uppsala University), Ingrid E. Lundberg(Karolinska University Hospital), Adil Mardinoğlu(King's College London), Erik Melén(Karolinska Institutet), Lingqi Meng(Science for Life Laboratory), Anne‐Sophie Merritt(Karolinska Institutet), Jan Mulder(Karolinska Institutet), M. Nguyen(Science for Life Laboratory), Jessica Nordlund(Uppsala University), Anna Norrby‐Teglund(Karolinska University Hospital), Antonella Notarnicola(Karolinska University Hospital), Piotr Nowak(Karolinska University Hospital), Jacob Odeberg(Science for Life Laboratory), Per Oksvold(Science for Life Laboratory), Tomas Olsson(Karolinska Institutet), Leonid Padyukov(Karolinska Institutet), Karlis Pauksens(Uppsala University), Fredrik Piehl(Karolinska Institutet), Elisa Pin(Science for Life Laboratory), Fredrik Pontén(Uppsala University), Natallia Rameika(Uppsala University), Anton Reepalu(Lund University), Joy Roy(Karolinska University Hospital), Jochen M. Schwenk(Science for Life Laboratory), Meltem Sen(Bakırköy Psychiatric Hospital), Antti Siika(Karolinska Institutet), Oscar E. Simonson(Uppsala University), Åsa Sivertsson(Science for Life Laboratory), Tobias Sjöblom(Uppsala University), Evelina Sjöstedt(Science for Life Laboratory), Lovisa Skoglund(Science for Life Laboratory), Anna Smed‐Sörensen(Karolinska University Hospital), Klara Sondén(Karolinska Institutet), Anders Sönnerborg(Karolinska University Hospital), Karin Stålberg(Uppsala University), Kristoffer Strålin(Karolinska University Hospital), Jonas Sundén‐Cullberg(Karolinska University Hospital), Christopher Sundling(Karolinska University Hospital), Thanadol Sutantiwanichkul(Science for Life Laboratory), Fernanda Costa Svedman(Karolinska University Hospital), Mattias Svensson(Karolinska University Hospital), Elisabet Svenungsson(Karolinska University Hospital), Tadepally Lakshmikanth(Karolinska Institutet), Khue Hua Tran-Minh(Science for Life Laboratory), Hasan Türkez(Atatürk University), Christian Unge(Karolinska University Hospital), Per Venge(Uppsala University), Marie Wahren‐Herlenius(Karolinska Institutet), Jakob Woessmann(Science for Life Laboratory), Hong Yang(Science for Life Laboratory), Ümit Haluk Yeşilkaya(Beth Israel Deaconess Medical Center), Meng Yuan(Science for Life Laboratory), Müjdat Zeybel(Koç University), Cheng Zhang(King's College London), Wen Zhong(Linköping University), Martin Zwahlen(Science for Life Laboratory), Kalle von Feilitzen(Science for Life Laboratory), Peter Nilsson(Science for Life Laboratory), Fredrik Edfors(Science for Life Laboratory), Mathias Uhlén(Science for Life Laboratory)
Cited by 21Open Access
Abstract
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.
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