SETBP1 variants outside the degron disrupt DNA-binding, transcription and neuronal differentiation capacity to cause a heterogeneous neurodevelopmental disorder

Maggie M. K. Wong(Max Planck Institute for Psycholinguistics), Simon E. Fisher(Radboud University Nijmegen), Sacha Weber(Centre Hospitalier Universitaire de Caen Normandie), Giovanni Battista Ferrero(5T Torino (Italy)), Alice Moroni(University of Turin), Arianna Vino(Max Planck Institute for Psycholinguistics), Ruth Braden(The University of Melbourne), Ezequiel Mendoza(Freie Universität Berlin), Samantha J. Turner(The University of Melbourne), Joery den Hoed(University of Zurich), Wendy K. Chung(Oregon Health & Science University), Francesca Novara(University of Pavia), Meghan Barnett(Women's and Children's Hospital), Lucinda Murray(Hunter Genetics), Aglaia Vignoli(University of Milan), David Mowat(UNSW Sydney), Ingrid E. Scheffer(The University of Melbourne), Michael S. Hildebrand, Angela Peron(University of Milan), Christopher Barnett(Women's and Children's Hospital), Frances Elmslie(St George’s University Hospitals NHS Foundation Trust), Fabio Sirchia(IRCCS Materno Infantile Burlo Garofolo), Rosalie A. Kampen(Max Planck Institute for Psycholinguistics), Elizabeth E. Palmer(The University of Sydney), Alexander J.M. Dingemans(Radboud University Nijmegen), Alfredo Brusco(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Angela Morgan(The University of Melbourne), Diana Carli(University of Turin), Bert B.A. de Vries(Radboud University Nijmegen), Nadieh A. Jansen(Radboud University Nijmegen), Ingrid M.B.H. van de Laar(Erasmus MC), Vanesa López‐González(Instituto de Salud Carlos III), Willemijn Claassen(Max Planck Institute for Psycholinguistics), Marion Gérard(Université de Caen Normandie), Bregje W.M. van Bon(Radboud University Nijmegen), Jean Corbally(Max Planck Institute for Psycholinguistics), Gökberk Alagöz(Max Planck Institute for Psycholinguistics)
Nature Communications
October 10, 2025
Cited by 4


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