A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma

William Zhao(Icahn School of Medicine at Mount Sinai), Thinh T. Nguyen(Icahn School of Medicine at Mount Sinai), Atharva Bhagwat(Icahn School of Medicine at Mount Sinai), Akhil Kumar(Icahn School of Medicine at Mount Sinai), Bruno Giotti(Icahn School of Medicine at Mount Sinai), Benjamin Kepecs(Icahn School of Medicine at Mount Sinai), Jason L. Weirather(Dana-Farber Cancer Institute), Navin R. Mahadevan(Brigham and Women's Hospital), Åsa Segerstolpe(Broad Institute), Komal Dolasia(Icahn School of Medicine at Mount Sinai), Jamshid Abdul‐Ghafar(Icahn School of Medicine at Mount Sinai), N. Besson(Dana-Farber Cancer Institute), Stephanie M. Jones(Dana-Farber Cancer Institute), Brian Y. Soong(Icahn School of Medicine at Mount Sinai), Chendi Li(Harvard University), Sébastien Vigneau(Dana-Farber Cancer Institute), Michal Slyper(Broad Institute), Isaac Wakiro(Memorial Sloan Kettering Cancer Center), Mei-Ju Su(Dana-Farber Cancer Institute), Karla Helvie(Dana-Farber Cancer Institute), Allison Frangieh(Dana-Farber Cancer Institute), Judit Jané‐Valbuena(Broad Institute), Orr Ashenberg(Broad Institute), Mark Awad(Dana-Farber Cancer Institute), Asaf Rotem(Dana-Farber Cancer Institute), Raphael Bueno(Brigham and Women's Hospital), Orit Rozenblatt–Rosen(Broad Institute), Kathleen L. Pfaff(Dana-Farber Cancer Institute), Scott J. Rodig(Brigham and Women's Hospital), Aaron N. Hata(Harvard University), Aviv Regev(Broad Institute), Bruce E. Johnson(Dana-Farber Cancer Institute), Alexander M. Tsankov(Broad Institute)
Nature Cancer
October 7, 2025
Cited by 6Open Access
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