ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver

Jiaxin Chen(Guangdong Academy of Sciences), Xiaoqing Wang(Roche (China)), Lu Li(Jiangsu Cancer Hospital), Jingsong Li(Shougang Institute of Technology), Chunyan Ji(Nanjing University of Chinese Medicine), Chengxing Shen(Shanghai Jiao Tong University), Hao Huang(University of Electronic Science and Technology of China), Guangre Xu(Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital), Liang Wen(University of California San Diego), Wenjie Tian(Massachusetts General Hospital), Yan Xiong(University of Electronic Science and Technology of China), Yu Chen(China-Japan Friendship Hospital), Chi Chen(Guiyang College of Traditional Chinese Medicine), Hui Huang(University of Electronic Science and Technology of China), Jin Zhou(Union Hospital), Guofang Xia(Shanghai Jiao Tong University), Peng Luo(Beihai People's Hospital), Peng Wei(Xinjiang University)
Communications Biology
October 2, 2025
10.1038/s42003-025-08818-x
Cited by 1

Related Papers

Real-time automatic detection system increases colonoscopic polyp and adenoma detection rates: a prospective randomised controlled study
|Gut|2019|817
Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute
|Nature Protocols|2019|485
Therapeutically Increasing MHC-I Expression Potentiates Immune Checkpoint Blockade
|Cancer Discovery|2021|286
Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer
|Science Advances|2023|220
In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target
|Cell|2021|200