Translational and clinical development of therapeutic siRNA and ASOs: current industry practices, perspectives, and recommendations

Jesper Kammersgaard Christensen(Novo Nordisk (Denmark)), Vibha Jawa(Bristol-Myers Squibb (Germany)), Darshana Jani(Bioanalytica (Switzerland)), Jingxian Chen(Biogen (United States)), Amir S. Youssef(Simulation Technologies (United States)), Xien Yu Chua(Alnylam Pharmaceuticals (United States)), Felix Huth(Novartis (Switzerland)), Guangnong Zhang(Novo Nordisk (Denmark)), Shirin Hooshfar(Eli Lilly (United States)), Christophe Husser(Roche (Switzerland)), Barent DuBois(Novo Nordisk (United States)), Katharina Root(Novartis (Switzerland)), Carol Kuo(Takeda (Japan)), Nicholas Colletti(Bristol-Myers Squibb (Germany)), Jeffrey C. Kurz(Alnylam Pharmaceuticals (United States)), Wenying Jian(Johnson & Johnson (United States)), Sara C. Humphreys(Bioanalytica (Switzerland)), V. Ravikanth(Eli Lilly (United States)), Matthew E. Albertolle(Electronic BioSciences (United States)), Helle Linnebjerg(Eli Lilly (United States)), Francis D. Gibbons(Takeda (Japan)), Girish R. Chopda(Novo Nordisk (Denmark)), Sumeet Singla(Novartis (Switzerland)), Steve R. Hood(Age UK), Chenxiao Tang(AstraZeneca (South Korea)), Krishna Aluri(Northeastern University), Annie Lumen(Amgen (United States)), Thomas N. Kakuda(Johnson & Johnson (United States)), Steven Zhang(Novo Nordisk (Denmark)), Pedro Morais(ProQR Therapeutics (Netherlands)), Rongrong Jiang(Eisai (Japan)), Sabine Lohmann(Roche (Switzerland)), Tao Niu(Sarepta Therapeutics (United States)), Jing Liu(Shenzhen Second People's Hospital), Linzhi Chen(Boehringer Ingelheim (Germany)), Shyam Kumar Gudey(Bioanalytica (Switzerland)), Swati Gupta(AbbVie (United States))
Nucleic Acids Research
August 15, 2025
Cited by 12


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