Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function
Marta Barisa(Great Ormond Street Hospital), Henrike Muller(Great Ormond Street Hospital), Elisa Zappa(Princess Máxima Center), Rivani Shah(Great Ormond Street Hospital), Juliane L. Buhl(Oncode Institute), Benjamin Draper(Great Ormond Street Hospital), Courtney Himsworth(Great Ormond Street Hospital), Chantelle Bowers(Great Ormond Street Hospital), Sophie Munnings-Tomes(Great Ormond Street Hospital), Marilena Nicolaidou(Great Ormond Street Hospital), Sonia Morlando(Great Ormond Street Hospital), Kathleen Birley(Great Ormond Street Hospital), Clara Leboreiro-Babe(Great Ormond Street Hospital), Alice Vitali(Great Ormond Street Hospital), Laura Privitera(Great Ormond Street Hospital), Kyle O’Sullivan(Great Ormond Street Hospital), Ailsa Greppi(Great Ormond Street Hospital), Magdalena Buschhaus, Mario Barrera Román(Oncode Institute), Sam de Blank(Oncode Institute), Femke van den Ham(Princess Máxima Center), Brenna R. van ‘t Veld(Princess Máxima Center), Gabrielle M. Ferry(Great Ormond Street Hospital), Jonathan Fisher(Great Ormond Street Hospital), Debarati Shome, Reza Nadafi, Israr-ul H. Ansari(University of Wisconsin–Madison), Rogier M. Reijmers, Stefano Giuliani(Great Ormond Street Hospital), Paul M. Sondel(University of Wisconsin–Madison), Laura Donovan(Great Ormond Street Hospital), Louis Chesler(University College London), Jan J. Molenaar(Princess Máxima Center), Jarno Drost(Oncode Institute), Anne C. Rios(Oncode Institute), Kerry Chester(Institute of Cancer Research), Judith Wienke(Princess Máxima Center), John Anderson(Great Ormond Street Hospital)
Cited by 10Open Access
Abstract
CAR-T / tumor target interaction times, CAR-T cell expansion and sustained tumor control. Lower checkpoint receptor expression does not correlate with enhanced anti-tumor function. These results provide further insights into design of anti-B7H3 CAR-T cells for antigen-dim cell targeting, and avoidance of antigen-dim tumor relapse.
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