Vaccination with mRNA-encoded membrane-anchored HIV envelope trimers elicited tier 2 neutralizing antibodies in a phase 1 clinical trial

K. Rachael Parks(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa), M. Juliana McElrath(Fred Hutch Cancer Center), Kellie J. MacPhee(Fred Hutch Cancer Center), David C. Montefiori(Duke University), Hong‐Van Tieu(New York Blood Center), Zoe Moodie(Fred Hutch Cancer Center), Caroline Reuter(Moderna Therapeutics (United States)), Kristen W. Cohen(Moderna Therapeutics (United States)), Mary Allen(National Institutes of Health), Sharon A. Riddler(University of Pittsburgh), Stephen R. Walsh(Beth Israel Deaconess Medical Center), Paul Goepfert(University of Maryland, Baltimore), Michael Kubitz(Scripps Research Institute), James G. Kublin(Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa), Elize Domin(Duke University), Sunny Himansu(Moderna Therapeutics (United States)), Georgia D. Tomaras(National Institutes of Health), Kathryn E. Stephenson(Beth Israel Deaconess Medical Center), Maija Anderson(Fred Hutch Cancer Center), Huiyin Lu(Fred Hutch Cancer Center), Michael C. Keefer(University of Rochester), William O. Hahn(University of Washington), Gabriel Ozorowski(Scripps Research Institute), Catherine Yen(National Institutes of Health), Christopher A. Cottrell(Scripps Research Institute), Dagna Laufer(International AIDS Vaccine Initiative), Alessia Liguori(Scripps Research Institute), Nicole Phelps(Scripps Research Institute), Nushin Alavi(Scripps Research Institute), Jesse L. Clark(University of Maryland, Baltimore), Brett Leav(University of Maryland, Baltimore), William R. Schief(Scripps Research Institute), Ian Frank(Norwegian Womens Public Health Association), Jack Heptinstall(Duke University), Erik Georgeson(Scripps Research Institute), Wen-Hsin Lee(Scripps Research Institute), Briana D. Furch(Fred Hutch Cancer Center), Shannon Grant(Fred Hutch Cancer Center), Magdalena E. Sobieszczyk(Columbia University Irving Medical Center), Ollivier Hyrien(Fred Hutch Cancer Center), Aaron Seese(Fred Hutch Cancer Center), Lindsey R. Baden(Brigham and Women's Hospital), Stephen C. De Rosa(University of Washington), Michael O. Duff(Fred Hutch Cancer Center), Lamar Ballweber-Fleming(Fred Hutch Cancer Center), Constanza Marini-Macouzet(Fred Hutch Cancer Center), Kelly E. Seaton(International Vaccine Institute)
Science Translational Medicine
July 30, 2025
Cited by 40


Related Papers