Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading

Sadeem Qdaisat; Brandon Wummer; Brian Stover; Dingpeng Zhang; James McGuiness; Frances Weidert; Jonathan Chardon‐Robles; Adam Grippin; Anna DeVries; Chong Zhao; Christiano Marconi; Aida Karachi; Chao Xie; Gabriel Jobin; Ruixuan Liu; Stephen Michel; Xiaojie Ma; Rachel Moor; Christina A. Von Roemeling; Duy Nguyen; Leighton Elliott; Nagheme Thomas; Arnav Barpujari; Hilary Geffrard; Yodarlynis Campaneria; Elizabeth Ogando‐Rivas; Cathleen Rabideau; Dhruvkumar Soni; Jianping Huang; Sheila Carrera‐Justiz; Kristianna M. Fredenburg; Natalie L. Silver; W. Gregory Sawyer; Maryam Rahman; John A. Ligon; Catherine Flores; Ji‐Hyun Lee; Duane A. Mitchell; Paul Castillo; Hector Mendez-Gomez; Elias Sayour

doi:10.1038/s41551-025-01380-1

Sensitization of tumours to immunotherapy by boosting early type-I interferon responses enables epitope spreading

Sadeem Qdaisat(Allen Institute for Brain Science), Brandon Wummer(Allen Institute for Brain Science), Brian Stover(University of Florida Health), Dingpeng Zhang(Allen Institute for Brain Science), James McGuiness(Allen Institute for Brain Science), Frances Weidert(Allen Institute for Brain Science), Jonathan Chardon‐Robles(Allen Institute for Brain Science), Adam Grippin(The University of Texas MD Anderson Cancer Center), Anna DeVries(Allen Institute for Brain Science), Chong Zhao(Allen Institute for Brain Science), Christiano Marconi(Allen Institute for Brain Science), Aida Karachi(Allen Institute for Brain Science), Chao Xie(Allen Institute for Brain Science), Gabriel Jobin(University of Florida Health), Ruixuan Liu(Allen Institute for Brain Science), Stephen Michel(Allen Institute for Brain Science), Xiaojie Ma(University of Florida Health), Rachel Moor(Allen Institute for Brain Science), Christina A. Von Roemeling(Allen Institute for Brain Science), Duy Nguyen(University of Florida), Leighton Elliott(University of Florida Health), Nagheme Thomas(Allen Institute for Brain Science), Arnav Barpujari(University of Florida Health), Hilary Geffrard(Allen Institute for Brain Science), Yodarlynis Campaneria(Allen Institute for Brain Science), Elizabeth Ogando‐Rivas(Allen Institute for Brain Science), Cathleen Rabideau(University of Florida Health), Dhruvkumar Soni(Allen Institute for Brain Science), Jianping Huang(Allen Institute for Brain Science), Sheila Carrera‐Justiz(University of Florida), Kristianna M. Fredenburg(University of Florida), Natalie L. Silver(Cleveland Clinic), W. Gregory Sawyer(University of Florida), Maryam Rahman(Allen Institute for Brain Science), John A. Ligon(University of Florida Health), Catherine Flores(Allen Institute for Brain Science), Ji‐Hyun Lee(University of Florida), Duane A. Mitchell(Allen Institute for Brain Science), Paul Castillo(University of Florida Health), Hector Mendez-Gomez(Allen Institute for Brain Science), Elias Sayour(Allen Institute for Brain Science)

Nature Biomedical Engineering

July 18, 2025

10.1038/s41551-025-01380-1

Cited by 18

Abstract

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