Base editing of trinucleotide repeats that cause Huntington’s disease and Friedreich’s ataxia reduces somatic repeat expansions in patient cells and in mice

Żaneta Matuszek(Broad Institute), David R. Liu(Broad Institute), Muzhou Wu(Massachusetts General Hospital), Heidi L. Rehm(Broad Institute), Shota Shibata(Harvard University), Mandana Arbab(Broad Institute), Yong Tao(Shanghai Jiao Tong University), Jun Xie(Hainan University), Maheswaran Kesavan(Massachusetts General Hospital), Jennie C. L. Roy(Harvard University), Gregory A. Newby(Broad Institute), Ricardo Mouro Pinto(Massachusetts General Hospital), Liam G. Fearnley(The University of Melbourne), Melanie Bahlo(Walter and Eliza Hall Institute of Medical Research), Ben Weisburd(MACOM (United States)), Alvin Hsu(Broad Institute), Ana Cristian(Broad Institute), Guangping Gao(University of Massachusetts Chan Medical School), Yu Tian(Brigham and Women's Hospital), Jing Zhao(Second Military Medical University)
Nature Genetics
May 26, 2025
Cited by 24


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