GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy

Carlos Cruchaga; Jigyasha Timsina; Chenyang Jiang; Daniel L. McCartney; Feifei Tao; Carolina Dalmasso; Jenna Najar; Federica Anastasi; Olena Ohlei; Raquel Puerta; Joseph Bradley; Daniel Western; Muhammad Ali; Ciyang Wang; Chengran Yang; Ying Wu; Menghan Liu; John Budde; Julie Williams; Rebecca Mahoney; Atahualpa Castillo-Morales; Timothy J. Hohman; Logan Dumitrescu; Ting‐Chen Wang; Niccoló Tesi; Silke Kern; Margda Wærn; Ingmer Skoog; Argonde van Harten; Wiesje M. van der Flier; Pascual Sánchez‐Juan; Eloy Rodríguez‐Rodríguez; Luca Kleineidam; Oliver Peters; Anja Schneider; Fahri Küçükali; Céline Bellenguez; Benjamin Grenier‐Boley; Sami Heikkinen; Itziar de Rojas; Dan Rujescu; Norbert Scherbaum; Lucrezia Hausner; Emrah Düzel; Timo Grimmer; Jens Wiltfang; Rik Vandenberghe; Sebastiaan Engelborghs; Stefanie Heilmann‐Heimbach; Matthias Schmid; Thomas Tegos; Nikolaos Scarmeas; Oriol Dols‐Icardo; Fermín Moreno; Jordi Pérez‐Tur; María J. Bullido; Raquel Sánchez‐Valle; Victoria Álvarez; Pablo García‐González; Pablo Mir; Luís Miguel Real; Gerard Piñol-Ripoll; José María García‐Alberca; Harro Seelaar; Inez Ramakers; Janne M. Papma; Marc Hulsman; Christoph Laske; Stefan Teipel; Josef Priller; Robert Perneczky; Katharina Büerger; Markus M. Nöthen; Piotr Lewczuk; Johannes Kornhuber; Wolfgang Maier; Harald Hampel; Ina Giegling; Oliver Goldhardt; Janine Diehl‐Schmid; Víctor Andrade; Michael T. Heneka; Lutz Froelich; Jonathan Vogelgsang; Caroline Graff; Håkan Thonberg; Abbe Ullgren; Goran Papenberg; Anne Boland; Jean‐François Deleuze; Michael Wagner; Frank Jessen; Henne Holstege; Cornelia M. van Duijn; Thibaud Lebouvier; Olivier Hanon; Ville Leinonen; Hilkka Soininen; Sanna‐Kaisa Herukka; Vilmantas Giedraitis; Malin Löwenmark; Lena Kilander; Patricia Genius; Blanca Rodríguez; Emma S. Luckett; Arcadi Navarro; Amanda Cano; Marta Marquié; Kaj Blennow; Henrik Zetterberg; Alberto Lleó; Merçé Boada; Agustı́n Ruiz; Virginia M.‐Y. Lee; Vivianna Van Deerlin; Yuetiva Deming; Sterling C. Johnson; Corinne D. Engelman; Pau Pástor; Ignacio Álvarez; Elaine R. Peskind; Amanda Heslegrave; Andrew J. Saykin; Kwangsik Nho; Suzanne E. Schindler; John C. Morris; David M. Holtzman; Eric McDade; Alan E. Renton; Alison Goate; Laura Ibáñez; Matthias Riemenschneider; Marilyn Albert; Simon M. Laws; Tenielle Porter; Eleanor K. O’Brien; Leslie M. Shaw; Betty M. Tijms; Martin Ingelsson; Pieter Jelle Visser; Mikko Hiltunen; Kristel Sleegers; Craig Ritchie; Rebecca Sims; Jean‐Charles Lambert; Natàlia Vilor‐Tejedor; Marı́a Fernández; Qingqin S. Li; Michael W. Nagle; Riccardo E. Marioni; Alfredo Ramı́rez; Lars Bertram; Sven J. van der Lee

doi:10.21203/rs.3.rs-6597595/v1

GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy

Carlos Cruchaga(Washington University in St. Louis), Jigyasha Timsina(Washington University in St. Louis), Chenyang Jiang(Amsterdam University Medical Centers), Daniel L. McCartney(University of Edinburgh), Feifei Tao(Eisai (United States)), Carolina Dalmasso(University of Cologne), Jenna Najar(Amsterdam University Medical Centers), Federica Anastasi(Pasqual Maragall Foundation), Olena Ohlei(University of Lübeck), Raquel Puerta(Universitat Internacional de Catalunya), Joseph Bradley(Washington University in St. Louis), Daniel Western(Washington University in St. Louis), Muhammad Ali, Ciyang Wang, Chengran Yang(Washington University in St. Louis), Ying Wu(Eisai (United States)), Menghan Liu(Washington University in St. Louis), John Budde, Julie Williams(Cardiff University), Rebecca Mahoney(UK Dementia Research Institute), Atahualpa Castillo-Morales(Cardiff University), Timothy J. Hohman(Vanderbilt University Medical Center), Logan Dumitrescu(Vanderbilt University Medical Center), Ting‐Chen Wang(Vanderbilt University Medical Center), Niccoló Tesi(Institute for Neurodegenerative Disorders), Silke Kern(University of Gothenburg), Margda Wærn, Ingmer Skoog(University of Gothenburg), Argonde van Harten(Amsterdam University Medical Centers), Wiesje M. van der Flier, Pascual Sánchez‐Juan(Fundacion Centro De Investigacion De Enfermedades Neurologicas), Eloy Rodríguez‐Rodríguez(Marqués de Valdecilla University Hospital), Luca Kleineidam(University of Bonn), Oliver Peters(Humboldt-Universität zu Berlin), Anja Schneider(University of Bonn), Fahri Küçükali, Céline Bellenguez(Inserm), Benjamin Grenier‐Boley(Inserm), Sami Heikkinen(University of Eastern Finland), Itziar de Rojas(Fundació ACE), Dan Rujescu(Medical University of Vienna), Norbert Scherbaum(University of Duisburg-Essen), Lucrezia Hausner(Heidelberg University), Emrah Düzel(German Center for Neurodegenerative Diseases), Timo Grimmer(Technical University of Munich), Jens Wiltfang(Universitätsmedizin Göttingen), Rik Vandenberghe(Universitair Ziekenhuis Leuven), Sebastiaan Engelborghs(University of Antwerp), Stefanie Heilmann‐Heimbach, Matthias Schmid(German Center for Neurodegenerative Diseases), Thomas Tegos(Aristotle University of Thessaloniki), Nikolaos Scarmeas, Oriol Dols‐Icardo(Hospital de Sant Pau), Fermín Moreno(Donostiako Unibertsitate Ospitalea), Jordi Pérez‐Tur(Instituto de Biomedicina de Valencia), María J. Bullido(Centro de Biología Molecular Severo Ochoa), Raquel Sánchez‐Valle(Hospital Clínic de Barcelona), Victoria Álvarez(Hospital Universitario Central de Asturias), Pablo García‐González(Fundació ACE), Pablo Mir(Hospital Universitario Virgen del Rocío), Luís Miguel Real(Hospital Universitario de Valme), Gerard Piñol-Ripoll(Federico Santa María Technical University), José María García‐Alberca(Instituto Andaluz de Ciencias de la Tierra), Harro Seelaar, Inez Ramakers(Maastricht University), Janne M. Papma(Erasmus MC), Marc Hulsman(Amsterdam University Medical Centers), Christoph Laske(German Center for Neurodegenerative Diseases), Stefan Teipel(German Center for Neurodegenerative Diseases), Josef Priller, Robert Perneczky(LMU Klinikum), Katharina Büerger(Ludwig-Maximilians-Universität München), Markus M. Nöthen, Piotr Lewczuk(Friedrich-Alexander-Universität Erlangen-Nürnberg), Johannes Kornhuber(Friedrich-Alexander-Universität Erlangen-Nürnberg), Wolfgang Maier(University of Bonn), Harald Hampel(Sorbonne Université), Ina Giegling(Medical University of Vienna), Oliver Goldhardt(Technical University of Munich), Janine Diehl‐Schmid, Víctor Andrade(University of Cologne), Michael T. Heneka(University Hospital Bonn), Lutz Froelich(Heidelberg University), Jonathan Vogelgsang(Universitätsmedizin Göttingen), Caroline Graff(Karolinska Institutet), Håkan Thonberg(Karolinska University Hospital), Abbe Ullgren(Karolinska Institutet), Goran Papenberg, Anne Boland(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Jean‐François Deleuze(Centre National de Recherche en Génomique Humaine), Michael Wagner(German Center for Neurodegenerative Diseases), Frank Jessen, Henne Holstege(Amsterdam UMC Location Vrije Universiteit Amsterdam), Cornelia M. van Duijn(University of Oxford), Thibaud Lebouvier(Inserm), Olivier Hanon(Université Paris Cité), Ville Leinonen(University of Eastern Finland), Hilkka Soininen(University of Eastern Finland), Sanna‐Kaisa Herukka(University of Eastern Finland), Vilmantas Giedraitis(Uppsala University), Malin Löwenmark(Uppsala University), Lena Kilander, Patricia Genius(Pasqual Maragall Foundation), Blanca Rodríguez(Pasqual Maragall Foundation), Emma S. Luckett(Amsterdam University Medical Centers), Arcadi Navarro(Pasqual Maragall Foundation), Amanda Cano(Fundació ACE), Marta Marquié(Universitat Internacional de Catalunya), Kaj Blennow(University of Gothenburg), Henrik Zetterberg(University of Gothenburg), Alberto Lleó(Universitat Autònoma de Barcelona), Merçé Boada(Universitat Internacional de Catalunya), Agustı́n Ruiz(Fundació ACE), Virginia M.‐Y. Lee(California University of Pennsylvania), Vivianna Van Deerlin(University of Pennsylvania), Yuetiva Deming(University of Wisconsin–Madison), Sterling C. Johnson(Wisconsin Society for Cardiovascular and Pulmonary Health & Rehabilitation), Corinne D. Engelman(University of Wisconsin–Madison), Pau Pástor(University Hospital Mútua de Terrassa), Ignacio Álvarez(Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol), Elaine R. Peskind, Amanda Heslegrave(UK Dementia Research Institute), Andrew J. Saykin(University School), Kwangsik Nho(Indiana University School of Medicine), Suzanne E. Schindler, John C. Morris, David M. Holtzman(Washington University in St. Louis), Eric McDade(Washington University in St. Louis), Alan E. Renton(Icahn School of Medicine at Mount Sinai), Alison Goate(Icahn School of Medicine at Mount Sinai), Laura Ibáñez(Washington University in St. Louis), Matthias Riemenschneider(Klinik und Poliklinik für Psychiatrie und Psychotherapie), Marilyn Albert, Simon M. Laws(Edith Cowan University), Tenielle Porter(Edith Cowan University), Eleanor K. O’Brien(Edith Cowan University), Leslie M. Shaw(University of Pennsylvania), Betty M. Tijms(Amsterdam University Medical Centers), Martin Ingelsson(Uppsala University), Pieter Jelle Visser(Amsterdam UMC Location Vrije Universiteit Amsterdam), Mikko Hiltunen(University of Eastern Finland), Kristel Sleegers(University of Antwerp), Craig Ritchie, Rebecca Sims(Cardiff University), Jean‐Charles Lambert(Institut Pasteur de Lille), Natàlia Vilor‐Tejedor(Hospital Del Mar), Marı́a Fernández, Qingqin S. Li(Janssen (United States)), Michael W. Nagle(Eisai (Japan)), Riccardo E. Marioni(University of Edinburgh), Alfredo Ramı́rez(University Hospital Cologne), Lars Bertram(University of Lübeck), Sven J. van der Lee(Amsterdam University Medical Centers)

Research Square

May 21, 2025

10.21203/rs.3.rs-6597595/v1

Cited by 1Open Access

Full Text

Abstract

Related Papers

No related papers found

Powered by citation graph analysis