Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation

Mingfei Wu(Zhejiang Institute of Mechanical and Electrical Engineering), Xiaowu Dong(Zhejiang University), Zheyuan Shen(Second Affiliated Hospital of Zhejiang University), Hengyuan Yu(Zhejiang University), Yiquan Wu(Pharmaceutical Biotechnology (Czechia)), Nengming Lin(Hangzhou First People's Hospital), Wen-Tao Wang(Pharmaceutical Biotechnology (Czechia)), Jinxin Che(Second Affiliated Hospital of Zhejiang University), Yong Chen(Pharmaceutical Biotechnology (Czechia)), Wenhai Huang(Hangzhou Medical College), Liuzhi Hu(Pharmaceutical Biotechnology (Czechia)), Tengfei Xu(China Agricultural University), Liteng Shen(Zhejiang Lab), Yuyuan Jin(Hangzhou Medical College), Xinfei Mao(Pharmaceutical Biotechnology (Czechia)), Bo Zhang(Hangzhou First People's Hospital), Shenxin Zeng(Hangzhou Medical College)
Journal of Medicinal Chemistry
May 16, 2025
Cited by 6


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