CRISPR engineering of armored CAR T cells enables tumor restricted payload delivery with enhanced efficacy and safety

Amanda Chen(Peter MacCallum Cancer Centre), Kah Min Yap(Peter MacCallum Cancer Centre), Joelle S. Kim, Kevin Sek(Peter MacCallum Cancer Centre), Yukuan Huang(Peter MacCallum Cancer Centre), Phoebe Dunbar(Peter MacCallum Cancer Centre), Volker Wiebking(Stanford University), Jesse Armitage(The University of Western Australia), Isabelle Munoz(Peter MacCallum Cancer Centre), Kirsten L. Todd(Peter MacCallum Cancer Centre), Emily B. Derrick(Peter MacCallum Cancer Centre), Dat Quoc Nguyen(Peter MacCallum Cancer Centre), Junming Tong(Peter MacCallum Cancer Centre), Cheok Weng Chan(Peter MacCallum Cancer Centre), Joel Lee(Peter MacCallum Cancer Centre), Thang Van Hoang(Peter MacCallum Cancer Centre), Thomas Cole(Peter MacCallum Cancer Centre), Jasmine Li(Peter MacCallum Cancer Centre), Maria N. de Menezes(Peter MacCallum Cancer Centre), C. Scheffler(Peter MacCallum Cancer Centre), Jason Waithman(The University of Western Australia), Jane Oliaro(Peter MacCallum Cancer Centre), Simon J. Harrison(Peter MacCallum Cancer Centre), Ian A. Parish(Peter MacCallum Cancer Centre), Junyun Lai(Peter MacCallum Cancer Centre), Matthew H. Porteus(Stanford University), Imran G. House(Peter MacCallum Cancer Centre), Phillip K. Darcy(Peter MacCallum Cancer Centre), Paul A. Beavis(Peter MacCallum Cancer Centre)
Research Square
April 28, 2025
Cited by 0Open Access
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