Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning

Rachel A. Silverstein(Harvard University), Nahye Kim(Harvard University), Ann-Sophie Kroell(Heidelberg University), Russell T. Walton(Massachusetts General Hospital), Justin Delano(Broad Institute), Rossano Butcher(Massachusetts Eye and Ear Infirmary), Martin Pačesa(SIB Swiss Institute of Bioinformatics), Baz Smith(Massachusetts General Hospital), Kathleen A. Christie(Harvard University), Leillani L. Ha(Massachusetts General Hospital), Ronald J. Meis(Wisconsin Institutes for Discovery), Aaron B. Clark(Allscripts (United States)), Aviv D. Spinner(Harvard University), Cícera R. Lazzarotto(St. Jude Children's Research Hospital), Yichao Li(St. Jude Children's Research Hospital), Azusa Matsubara(St. Jude Children's Research Hospital), Elizabeth Urbina-Sánchez(St. Jude Children's Research Hospital), Gary A. Dahl(Wisconsin Institutes for Discovery), Bruno E. Correia(SIB Swiss Institute of Bioinformatics), Debora S. Marks(Broad Institute), Shengdar Q. Tsai(St. Jude Children's Research Hospital), Luca Pinello(Broad Institute), Suk See De Ravin(National Institutes of Health), Qin Liu(Massachusetts Eye and Ear Infirmary), Benjamin P. Kleinstiver(Harvard University)
Nature
April 22, 2025
Cited by 58Open Access
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