Nitrogen-Based Organofluorine Functional Molecules: Synthesis and Applications

Abstract

Fluorine and nitrogen form a successful partnership in organic synthesis, medicinal chemistry, and material sciences. Although fluorine-nitrogen chemistry has a long and rich history, this field has received increasing interest and made remarkable progress over the past two decades, driven by recent advancements in transition metal and organocatalysis and photochemistry. This review, emphasizing contributions from 2015 to 2023, aims to update the state of the art of the synthesis and applications of nitrogen-based organofluorine functional molecules in organic synthesis and medicinal chemistry. In dedicated sections, we first focus on fluorine-containing reagents organized according to the type of fluorine-containing groups attached to nitrogen, including N-F, N-RF, N-SRF, and N-ORF. This review also covers nitrogen-linked fluorine-containing building blocks, catalysts, pharmaceuticals, and agrochemicals, underlining these components’ broad applicability and growing importance in modern chemistry.