Molecular and Genetic Insights Into Human Ovarian Aging From Single-Nuclei Multi-omics Analyses

Chen Jin; Xizhe Wang; Jiping Yang; Seung-Soo Kim; Adam D. Hudgins; Amir Gamliel; Mingzhuo Pei; Daniela Contreras; Melody Devos; Qinghua Guo; Jan Vijg; Marco Conti; Jan H.J. Hoeijmakers; Judith Campisi; Rogerio A. Løbo; Zev Williams; Michael G. Rosenfeld; Yousin Suh

doi:10.1097/ogx.0000000000001382

Molecular and Genetic Insights Into Human Ovarian Aging From Single-Nuclei Multi-omics Analyses

Chen Jin, Xizhe Wang, Jiping Yang, Seung-Soo Kim, Adam D. Hudgins, Amir Gamliel, Mingzhuo Pei, Daniela Contreras, Melody Devos, Qinghua Guo, Jan Vijg, Marco Conti, Jan H.J. Hoeijmakers, Judith Campisi, Rogerio A. Løbo, Zev Williams, Michael G. Rosenfeld, Yousin Suh

Obstetrical & Gynecological Survey

March 1, 2025

10.1097/ogx.0000000000001382

Cited by 1

Abstract

(Abstracted from Nat Aging 2024. doi: 10.1038/s43587-024-00762-5) Ovaries are the crux of the female reproductive system and are the first organs to show signs of aging and thus the slowing of reproductive processes, characterized by a reduced number and quality of oocytes. The more a woman ages, the higher the risk of infertility or aneuploidy and congenital disabilities in their children.

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