Medical SAM adapter: Adapting segment anything model for medical image segmentation

Junde Wu(National University of Singapore), Ziyue Wang(National University of Singapore), Mingxuan Hong(National University of Singapore), Wei Ji(University of Alberta), Huazhu Fu(Agency for Science, Technology and Research), Yanwu Xu(Singapore Eye Research Institute), Min Xu(Mohamed bin Zayed University of Artificial Intelligence), Yueming Jin(National University of Singapore)
Medical Image Analysis
March 19, 2025
Cited by 320Open Access
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Abstract

The Segment Anything Model (SAM) has recently gained popularity in the field of image segmentation due to its impressive capabilities in various segmentation tasks and its prompt-based interface. However, recent studies and individual experiments have shown that SAM underperforms in medical image segmentation due to the lack of medical-specific knowledge. This raises the question of how to enhance SAM's segmentation capability for medical images. We propose the Medical SAM Adapter (Med-SA), which is one of the first methods to integrate SAM into medical image segmentation. Med-SA uses a light yet effective adaptation technique instead of fine-tuning the SAM model, incorporating domain-specific medical knowledge into the segmentation model. We also propose Space-Depth Transpose (SD-Trans) to adapt 2D SAM to 3D medical images and Hyper-Prompting Adapter (HyP-Adpt) to achieve prompt-conditioned adaptation. Comprehensive evaluation experiments on 17 medical image segmentation tasks across various modalities demonstrate the superior performance of Med-SA while updating only 2% of the SAM parameters (13M). Our code is released at https://github.com/KidsWithTokens/Medical-SAM-Adapter.


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