Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Yi Fu; Max Land; Tamar Kavlashvili; Ruobing Cui; Min‐Soo Kim; Emily DeBitetto; Toby Lieber; Keun Woo Ryu; Elim Choi; Ignas Masilionis; Rahul Saha; Meril Takizawa; Daphne Baker; Marco Tigano; Caleb A. Lareau; Ed Reznik; Roshan Sharma; Ronan Chaligné; C. Thompson; Dana Pe’er; Agnel Sfeir

doi:10.1016/j.cell.2025.02.009

Engineering mtDNA deletions by reconstituting end joining in human mitochondria

Yi Fu(Memorial Sloan Kettering Cancer Center), Max Land(Memorial Sloan Kettering Cancer Center), Tamar Kavlashvili(Memorial Sloan Kettering Cancer Center), Ruobing Cui(Memorial Sloan Kettering Cancer Center), Min‐Soo Kim(Memorial Sloan Kettering Cancer Center), Emily DeBitetto(Memorial Sloan Kettering Cancer Center), Toby Lieber(Memorial Sloan Kettering Cancer Center), Keun Woo Ryu(Memorial Sloan Kettering Cancer Center), Elim Choi(Memorial Sloan Kettering Cancer Center), Ignas Masilionis(Memorial Sloan Kettering Cancer Center), Rahul Saha(Memorial Sloan Kettering Cancer Center), Meril Takizawa(Memorial Sloan Kettering Cancer Center), Daphne Baker(Memorial Sloan Kettering Cancer Center), Marco Tigano(Thomas Jefferson University), Caleb A. Lareau(Memorial Sloan Kettering Cancer Center), Ed Reznik(Memorial Sloan Kettering Cancer Center), Roshan Sharma(Memorial Sloan Kettering Cancer Center), Ronan Chaligné(Memorial Sloan Kettering Cancer Center), C. Thompson(Memorial Sloan Kettering Cancer Center), Dana Pe’er(Memorial Sloan Kettering Cancer Center), Agnel Sfeir(Memorial Sloan Kettering Cancer Center)

Cell

March 10, 2025

10.1016/j.cell.2025.02.009

Cited by 26Open Access

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