High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics

Yufen Xiao; Xizhen Lian; Yehui Sun; Yun‐Chieh Sung; Amogh Vaidya; Zexiang Chen; Ankit Gupta; Sumanta Chatterjee; Lining Zheng; Erick Guerrero; Xu Wang; Lukas Farbiak; Yangyang Yang; Marc I. Diamond; Cecília Leal; Jeffrey G. McDonald; Daniel J. Siegwart

doi:10.1038/s41563-024-02116-3

High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics

Yufen Xiao(The University of Texas Southwestern Medical Center), Xizhen Lian(The University of Texas Southwestern Medical Center), Yehui Sun(The University of Texas Southwestern Medical Center), Yun‐Chieh Sung(The University of Texas Southwestern Medical Center), Amogh Vaidya(The University of Texas Southwestern Medical Center), Zexiang Chen(The University of Texas Southwestern Medical Center), Ankit Gupta(The University of Texas Southwestern Medical Center), Sumanta Chatterjee(The University of Texas Southwestern Medical Center), Lining Zheng(University of Illinois Urbana-Champaign), Erick Guerrero(The University of Texas Southwestern Medical Center), Xu Wang(The University of Texas Southwestern Medical Center), Lukas Farbiak(The University of Texas Southwestern Medical Center), Yangyang Yang(The University of Texas Southwestern Medical Center), Marc I. Diamond(The University of Texas Southwestern Medical Center), Cecília Leal(University of Illinois Urbana-Champaign), Jeffrey G. McDonald(The University of Texas Southwestern Medical Center), Daniel J. Siegwart(Southwestern Medical Center)

Nature Materials

February 28, 2025

10.1038/s41563-024-02116-3

Cited by 53Open Access

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