Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis

Rachael I. Scahill(National Hospital for Neurology and Neurosurgery), Sarah J. Tabrizi(Huntington's Disease Association), Harpreet Hyare(National Hospital for Neurology and Neurosurgery), Douglas R. Langbehn(University of Iowa), Edward J. Wild(Huntington's Disease Association), Carlos Estevez‐Fraga(Huntington's Disease Association), Kate Fayer(Huntington's Disease Association), Christelle Langley(University of Cambridge), Mitsuko Nakajima(Huntington's Disease Association), Harry Knights(Huntington's Disease Association), James B. Rowe(MRC Cognition and Brain Sciences Unit), Barbara J. Sahakian(University of Cambridge), Michela Leocadi(Huntington's Disease Association), Sophia Weiner(Institute of Neurobiology), Darren G. Monckton(University of Glasgow), Jeffrey D. Long(University of Iowa), Yara Hassan(Huntington's Disease Association), Marc Ciosi, Mena Farag(Huntington's Disease Association), Ian B. Malone(UK Dementia Research Institute), Amanda Heslegrave(UK Dementia Research Institute), Geraint Rees(Global College), Henrik Zetterberg(University of Wisconsin–Madison), Trevor W. Robbins(University of Cambridge), Olivia Thackeray(Huntington's Disease Association), Hui Zhang(Jiangsu University of Science and Technology), Christopher S. Parker(University College London), Michael Murphy(Huntington's Disease Association), Nehaa K. P. Ponraj(University of Glasgow), Nicola Z. Hobbs(Huntington's Disease Association), Cristina Sampaio(Dorothea Haus Ross Foundation), John Rönnholm(University of Gothenburg), Johan Gobom(Sahlgrenska University Hospital)
Nature Medicine
January 17, 2025
Cited by 53


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