Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism
Ronal M. Peralta(UPMC Hillman Cancer Center), Greg M. Delgoffe(University of Pittsburgh)
Cited by 134
Related Papers
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
|Nature Immunology|2011|1.1k
4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
|The Journal of Experimental Medicine|2018|302
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
|Nature Immunology|2022|254
Metabolic waypoints during T cell differentiation
|Nature Immunology|2024|83
An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment
|The Journal of Experimental Medicine|2023|44