Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases
Gue‐Ho Hwang(Seoul National University Hospital), Sangsu Bae(New Generation University College)
Cited by 44
Related Papers
Construction of non-canonical PAM-targeting adenosine base editors by restriction enzyme-free DNA cloning using CRISPR-Cas9
|Scientific Reports|2019|77
Detailed mechanisms for unintended large DNA deletions with CRISPR, base editors, and prime editors
|bioRxiv (Cold Spring Harbor Laboratory)|2024|5
Precise adenine base editors that exhibit minimized cytosine catalysis
|Research Square|2020|3
Engineered ADARs enable single-nucleotide resolution DNA A-to-G editing without bystander effects
|bioRxiv (Cold Spring Harbor Laboratory)|2025|1
Site-specific replacement of large-scale DNA fragments in human cells
|bioRxiv (Cold Spring Harbor Laboratory)|2025|1