Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity

Jason J. Kwon(Dana-Farber Cancer Institute), Andrew J. Aguirre(Broad Institute), Christopher T. Lemke(Broad Institute), Eejung Kim(Broad Institute), Timothy H. Tran(Frederick National Laboratory for Cancer Research), Dhirendra K. Simanshu(Leidos (United States)), Julien Dilly(Massachusetts Institute of Technology), Kevin M. Haigis(Harvard University), Dwight V. Nissley(Leidos (United States)), John G. Doench(Broad Institute), Yuemin Bian(Broad Institute), Sean A. Misek(Michigan State University), Andrew O. Giacomelli(Humber Polytechnic), Arvind Ravi(Broad Institute), Shengwu Liu(Broad Institute), Dana Rabara(Frederick National Laboratory for Cancer Research), William C. Hahn(Broad Institute), Seav Huong Ly(Broad Institute), Srisathiyanarayanan Dharmaiah(Frederick Community College), Xiaoping Yang(Broad Institute), Andrew G. Stephen(Frederick National Laboratory for Cancer Research), Dominic Esposito(Leidos (United States)), Andrew L. Hong(Emory Healthcare), Frank McCormick(Frederick National Laboratory for Cancer Research), David E. Root(Broad Institute), Belinda Wang(The University of Sydney), Timothy J. Waybright(Frederick National Laboratory for Cancer Research), Rameen Beroukhim(Broad Institute), Kevin S. Kapner(Broad Institute)
bioRxiv (Cold Spring Harbor Laboratory)
October 25, 2024
Cited by 9


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