Use of UMFNPs/Ce6@MBs in multimodal imaging-guided sono-photodynamic combination therapy for hepatocellular carcinoma

Lijun Xing(Hubei University of Medicine), Xiaoting Yang(Peking University Shenzhen Hospital), Jianhua Bai(Peking University Shenzhen Hospital), Chunting Zhong(Peking University Shenzhen Hospital), Jing Cai(Sun Yat-sen University), Qing Dan(Peking University Shenzhen Hospital), Yiran Ji(Peking University Shenzhen Hospital), Bingxuan Xu(Peking University Shenzhen Hospital), Keyan Yu(Peking University Shenzhen Hospital), Xiaoyu Chen(Peking University Shenzhen Hospital), Yulong Qi(Peking University Shenzhen Hospital), Li Li(Sun Yat-sen University), Yun Chen(Peking University Shenzhen Hospital), Xintao Shuai(Sun Yat-sen University), Guanxun Cheng(Peking University Shenzhen Hospital), Li Liu(Peking University Shenzhen Hospital), Tingting Zheng(Peking University Shenzhen Hospital)
Biomaterials Science
October 24, 2024
10.1039/d4bm00613e
Cited by 8Open Access
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Abstract

magnetic resonance imaging of tumor-bearing mice, and the released Ce6 can provide fluorescence imaging function at the same time. Because UMFNPs/Ce6@MB ultrasonic microbubbles show good ultrasonic imaging results, UMFNPs/Ce6@MBs can simultaneously provide multi-modal imaging functions for magnetic resonance imaging (MRI), ultrasound and fluorescence imaging. In conclusion, UMFNPs/Ce6@MBs realize the synergistic treatment of SDT and PDT under multi-mode near-infrared fluorescence imaging and CEUS monitoring, demonstrating its great potential in tumor precision medicine.

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