LTP expression mediated by autonomous activity of GluN2B-bound CaMKII
Nicole L. Rumian(University of Colorado Anschutz Medical Campus), C. Madison Barker(University of Colorado Anschutz Medical Campus), Matthew E. Larsen(University of Colorado Anschutz Medical Campus), Jonathan E. Tullis(University of Colorado Anschutz Medical Campus), Ronald K. Freund(University of Colorado Anschutz Medical Campus), Amir Taslimi(University of Colorado Anschutz Medical Campus), Steven J. Coultrap(University of Colorado Anschutz Medical Campus), Chandra L. Tucker(University of Colorado Anschutz Medical Campus), Mark L. Dell’Acqua(University of Colorado Anschutz Medical Campus), K. Ulrich Bayer(University of Colorado Anschutz Medical Campus)
Cited by 20Open Access
Abstract
-independent autonomous CaMKII activity, and we show that this enzymatic activity is dispensable for LTP induction (within 5 min) but required for a subsequent LTP phase (within 15 min). This requirement for CaMKII activity provides an objective temporal definition for the intermediary phase of LTP expression. Later LTP maintenance may still require structural functions of GluN2B-bound CaMKII but not the resulting enzymatic CaMKII activity or their co-condensation. Thus, autonomous CaMKII activity mediates post-induction LTP but (1) via GluN2B binding, not T286 autophosphorylation, and (2) during the intermediary expression phase rather than for long-term maintenance.
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