Neuronal wiring diagram of an adult brain
Sven Dorkenwald(Princeton University), Arie Matsliah(Princeton University), Amy Sterling(Massachusetts Eye and Ear Infirmary), Philipp Schlegel(MRC Laboratory of Molecular Biology), Szi-chieh Yu(Princeton University), Claire McKellar(Princeton University), Albert Lin(Princeton University), Marta Costa(University of Cambridge), Katharina Eichler(University of Cambridge), Yijie Yin(University of Cambridge), Will Silversmith(Princeton University), Casey M Schneider-Mizell(Allen Institute for Brain Science), Chris S. Jordan(Princeton University), Derrick Brittain(Allen Institute for Brain Science), Akhilesh Halageri(Princeton University), Kai Kuehner(Princeton University), Oluwaseun Ogedengbe(Princeton University), R. A. Morey(Princeton University), Jay Gager(Princeton University), Krzysztof Kruk(Massachusetts Eye and Ear Infirmary), Eric Perlman, Runzhe Yang(Princeton University), David Deutsch(Princeton University), Doug Bland(Princeton University), Marissa Sorek(Massachusetts Eye and Ear Infirmary), Ran Lu(Princeton University), Thomas Macrina(Princeton University), Kisuk Lee(Princeton University), J. Alexander Bae(Princeton University), Shang Mu(Princeton University), Barak Nehoran(Princeton University), Eric Mitchell(Princeton University), Sergiy Popovych(Princeton University), Jingpeng Wu(Princeton University), Zhen Jia(Princeton University), Manuel Castro(Princeton University), Nico Kemnitz(Princeton University), Dodam Ih(Princeton University), Alexander Shakeel Bates(Harvard University), Nils Eckstein(Howard Hughes Medical Institute), Jan Funke(Howard Hughes Medical Institute), Forrest Collman(Allen Institute for Brain Science), Davi D. Bock(University of Vermont), Gregory S.X.E. Jefferis(MRC Laboratory of Molecular Biology), H. Sebastian Seung(Princeton University), Mala Murthy(Princeton University), Zairene Lenizo(University of Mindanao), Austin T. Burke(Princeton University), Kyle Patrick Willie(Princeton University), Nikitas Serafetinidis(Massachusetts Eye and Ear Infirmary), Nashra Hadjerol(University of Mindanao), Ryan Willie(Princeton University), Ben Silverman(Princeton University), John Anthony Ocho(University of Mindanao), Joshua Bañez(University of Mindanao), Rey Adrian Candilada(University of Mindanao), Anne Kristiansen(Massachusetts Eye and Ear Infirmary), Nelsie Panes(University of Mindanao), Arti Yadav(Büchi Labortechnik), Remer Tancontian(University of Mindanao), Shirleyjoy Serona(University of Mindanao), Jet Ivan Dolorosa(University of Mindanao), Kendrick Joules Vinson(University of Mindanao), Dustin Garner(University of California, Santa Barbara), Regine Salem(University of Mindanao), Ariel Dagohoy(University of Mindanao), Jaime Skelton(Massachusetts Eye and Ear Infirmary), Mendell Lopez(University of Mindanao), Laia Serratosa Capdevila(University of Cambridge), Griffin Badalamente(University of Cambridge), Thomas Stocks(Massachusetts Eye and Ear Infirmary), Anjali Pandey(Büchi Labortechnik), Darrel Jay Akiatan(University of Mindanao), James Hebditch(Princeton University), Celia David(Princeton University), Dharini Sapkal(Büchi Labortechnik), Shaina Mae Monungolh(University of Mindanao), Varun Sane(University of Cambridge), Mark Lloyd Pielago(University of Mindanao), Miguel Albero(University of Mindanao), Jacquilyn Laude(University of Mindanao), Márcia dos Santos(University of Cambridge), Zeba Vohra(Büchi Labortechnik), Kaiyu Wang(Howard Hughes Medical Institute), Allien Mae Gogo(University of Mindanao), Emil Kind(Freie Universität Berlin), Alvin Josh Mandahay(University of Mindanao), Chereb Martinez(University of Mindanao), John David Asis(University of Mindanao), Chitra Nair(Büchi Labortechnik), Dhwani Patel(Büchi Labortechnik), Marchan Manaytay(University of Mindanao), Imaan F. M. Tamimi(University of Cambridge), Clyde Angelo Lim(University of Mindanao), Philip Lenard Ampo(University of Mindanao), Michelle Darapan Pantujan(University of Mindanao), Alexandre Javier(University of Cambridge), Daril Bautista(University of Mindanao), Rashmita Rana(Büchi Labortechnik), Jansen Seguido(University of Mindanao), Bhargavi Parmar(Büchi Labortechnik), John Clyde Saguimpa(University of Mindanao), Merlin Moore(Princeton University), Markus William Pleijzier(MRC Laboratory of Molecular Biology), Mark Larson(IIT@Harvard), Joseph Hsu(University of Cambridge), Itisha Joshi(Büchi Labortechnik), Dhara Kakadiya(Büchi Labortechnik), Amalia Braun(Max Planck Institute for Intelligent Systems), Cathy Pilapil(University of Mindanao), Marina Gkantia(University of Cambridge), Kaushik Parmar(Büchi Labortechnik), Quinn Vanderbeck(Harvard University), Irene Salgarella(University of Cambridge), Christopher Dunne(University of Cambridge), Eva Munnelly(University of Cambridge), Chan Hyuk Kang(Sungkyunkwan University), Lena Lörsch(Johannes Gutenberg University Mainz), Jinmook Lee(Sungkyunkwan University), Lucia Kmecova(University of Puerto Rico, Medical Sciences Campus), Gizem Sancer(Yale University), Christa Baker(Princeton University), Jenna Joroff(Harvard University), Steven Calle(University of Puerto Rico, Medical Sciences Campus), Yashvi Patel(Büchi Labortechnik), Olivia Sato(IIT@Harvard), Siqi Fang(University of Cambridge), Janice Salocot(University of Mindanao), Farzaan Salman(West Virginia University), Sebastian Molina-Obando(Johannes Gutenberg University Mainz), Paul Brooks(University of Cambridge), Mai Bui(Mount Holyoke College), Matthew Lichtenberger(Massachusetts Eye and Ear Infirmary), Edward Tamboboy(University of Mindanao), Katie Molloy(IIT@Harvard), Alexis E. Santana-Cruz(University of Puerto Rico, Medical Sciences Campus), Anthony Hernandez(Massachusetts Eye and Ear Infirmary), Seongbong Yu(Princeton University), Arzoo Diwan(Büchi Labortechnik), Monika Patel(Büchi Labortechnik), Travis R. Aiken(Massachusetts Eye and Ear Infirmary), Sarah Morejohn(Princeton University), Sanna Koskela(Howard Hughes Medical Institute), Tansy Yang(Howard Hughes Medical Institute), Daniel Lehmann(Massachusetts Eye and Ear Infirmary), Jonas Chojetzki(Johannes Gutenberg University Mainz), Sangeeta Sisodiya(Büchi Labortechnik), Selden Koolman(Princeton University), Philip K. Shiu(University of California, Berkeley), Sky Cho(Mount Holyoke College), Annika Bast(Johannes Gutenberg University Mainz), Brian Reicher(IIT@Harvard), Marlon Blanquart(University of Cambridge), Lucy Houghton(University of California, Santa Barbara), Hyungjun Choi(Sungkyunkwan University), Maria Ioannidou(Johannes Gutenberg University Mainz), Matt Collie(IIT@Harvard), Joanna Eckhardt(Princeton University), Benjamin Gorko(University of California, Santa Barbara), Li Guo(University of California, Santa Barbara), Zhihao Zheng(Princeton University), Alisa Poh(The University of Queensland), Marina Lin(Mount Holyoke College), István Taisz(MRC Laboratory of Molecular Biology), Wes Murfin(Engineering Data Management), Álvaro Sanz Díez(Columbia University), Nils Reinhard(University of Würzburg), Peter Gibb(Harvard University), Nidhi Patel(Büchi Labortechnik), Sandeep Kumar(Princeton University), Minsik Yun(Gwangju Institute of Science and Technology), Megan Wang(Princeton University), Devon Jones(Princeton University), Lucas Encarnacion-Rivera(Stanford University), Annalena Oswald(Johannes Gutenberg University Mainz), Akanksha Jadia(Büchi Labortechnik), Mert Erginkaya(Champalimaud Foundation), Nik Drummond(University of Cambridge), Leonie Walter(Freie Universität Berlin), Ibrahim Tastekin(Champalimaud Foundation), Xin Zhong(Freie Universität Berlin), Yuta Mabuchi(Cornell University), Fernando J. Figueroa Santiago(University of Puerto Rico, Medical Sciences Campus), Urja Verma(Büchi Labortechnik), Nick Byrne(IIT@Harvard), Edda Kunze(Freie Universität Berlin), Thomas Crahan(University of California, Santa Barbara), Ryan Margossian(Massachusetts Eye and Ear Infirmary), Haein Kim(Cornell University), Iliyan Georgiev(Massachusetts Eye and Ear Infirmary), Fabianna Szorenyi(University of Puerto Rico, Medical Sciences Campus), Atsuko Adachi(Columbia University), Benjamin Bargeron(Max Planck Florida Institute for Neuroscience), Tomke Stürner(MRC Laboratory of Molecular Biology), Damian Demarest(University of Bonn), Burak Gür(Johannes Gutenberg University Mainz), Andrea N. Becker(Massachusetts Eye and Ear Infirmary), Robert Turnbull(University of Cambridge), Ashley Morren(Massachusetts Eye and Ear Infirmary), Andrea Sandoval(University of California, Berkeley), Anthony Moreno-Sanchez(Drexel University), Diego A. Pacheco(Harvard University), Eleni Samara(Max Planck Institute for Intelligent Systems), Haley Croke(Drexel University), Alexander Thomson(Howard Hughes Medical Institute), Connor Laughland(Howard Hughes Medical Institute), Suchetana B. Dutta(Freie Universität Berlin), Paula Guiomar Alarcón de Antón(Freie Universität Berlin), Binglin Huang(University of California, Santa Barbara), Patricia Pujols(University of Puerto Rico, Medical Sciences Campus), Isabel Haber(IIT@Harvard), Amanda González-Segarra(University of California, Berkeley), Daniel T. Choe(Seoul National University), Veronika Lukyanova(Newcastle University), Nino Mancini(Max Planck Florida Institute for Neuroscience), Zequan Liu(RWTH Aachen University), Tatsuo Okubo(Harvard University), Miriam A. Flynn(Howard Hughes Medical Institute), Gianna Vitelli(Max Planck Florida Institute for Neuroscience), Meghan Laturney(University of California, Berkeley), Feng Li(Howard Hughes Medical Institute), Shuo Cao(California Institute of Technology), Carolina Manyari-Diaz(Max Planck Florida Institute for Neuroscience), Hyunsoo Yim(Seoul National University), Anh Duc Le(Drexel University), Kate Maier(Max Planck Florida Institute for Neuroscience), Seungyun Yu(Princeton University), Yeonju Nam(Sungkyunkwan University), Daniel Bąba(Massachusetts Eye and Ear Infirmary), Amanda Abusaif(University of California, Berkeley), Audrey Francis(Rockefeller University), Jesse Gayk(Büchi Labortechnik), Sommer S. Huntress(Mount Holyoke College), Raquel Barajas(Champalimaud Foundation), Mindy Kim(IIT@Harvard), Xinyue Cui(Cornell University), Gabriella R. Sterne(University of California, Berkeley), Anna Li(Harvard University), Keehyun Park(Sungkyunkwan University), Georgia Dempsey(University of Cambridge), Alan Mathew(University of Cambridge), Jinseong Kim(Sungkyunkwan University), Taewan Kim(Sungkyunkwan University), Guan-ting Wu(National Dong Hwa University), Serene Dhawan(The Francis Crick Institute), Margarida Brotas(Champalimaud Foundation), Cheng-hao Zhang(National Dong Hwa University), Shanice Bailey(University of Cambridge), Alexander Del Toro(University of California, Berkeley), Runzhe Yang(Princeton University), Stephan Gerhard(Aware Global Hospital), Andrew Champion(MRC Laboratory of Molecular Biology), David J. Anderson(California Institute of Technology), Rudy Behnia(Columbia University), Salil S. Bidaye(Max Planck Florida Institute for Neuroscience), Alexander Borst(Max Planck Institute for Intelligent Systems), Eugenia Chiappe(Champalimaud Foundation), Kenneth J. Colodner(Mount Holyoke College), Andrew Dacks(West Virginia University), Barry Dickson(Howard Hughes Medical Institute), Denise Garcia(Drexel University), Stefanie Hampel(University of Puerto Rico, Medical Sciences Campus), Volker Hartenstein(University of California, Los Angeles), Bassem Hassan(Freie Universität Berlin), Charlotte Helfrich-Forster(University of Würzburg), Wolf Huetteroth(Leipzig University), Jinseop Kim(Sungkyunkwan University), Sung Soo Kim(University of California, Santa Barbara), Young-Joon Kim(Gwangju Institute of Science and Technology), Jae Young Kwon(Sungkyunkwan University), Wei-Chung Lee(Harvard University), Gerit A. Linneweber(Freie Universität Berlin), Gaby Maimon(Rockefeller University), Richard Mann(Columbia University), Stéphane Noselli(Centre National de la Recherche Scientifique), Michael Pankratz(University of Bonn), Lucia Prieto-Godino(The Francis Crick Institute), Jenny Read(Newcastle University), Michael Reiser(Howard Hughes Medical Institute), Katie von Reyn(Drexel University), Carlos Ribeiro(Champalimaud Foundation), Kristin Scott(University of California, Berkeley), Andrew M. Seeds(University of Puerto Rico, Medical Sciences Campus), Mareike Selcho(Leipzig University), Marion Silies(Johannes Gutenberg University Mainz), Julie Simpson(University of California, Santa Barbara), Scott Waddell(University of Oxford), Mathias F. Wernet(Freie Universität Berlin), Rachel I. Wilson(Harvard University), Fred W. Wolf(University of California, Merced), Zepeng Yao(University of Florida), Nilay Yapici(Cornell University), Meet Zandawala(University of Würzburg)
Cited by 482Open Access
Abstract
Abstract Connections between neurons can be mapped by acquiring and analysing electron microscopic brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative 1–6 , but nevertheless inadequate for understanding brain function more globally. Here we present a neuronal wiring diagram of a whole brain containing 5 × 10 7 chemical synapses 7 between 139,255 neurons reconstructed from an adult female Drosophila melanogaster 8,9 . The resource also incorporates annotations of cell classes and types, nerves, hemilineages and predictions of neurotransmitter identities 10–12 . Data products are available for download, programmatic access and interactive browsing and have been made interoperable with other fly data resources. We derive a projectome—a map of projections between regions—from the connectome and report on tracing of synaptic pathways and the analysis of information flow from inputs (sensory and ascending neurons) to outputs (motor, endocrine and descending neurons) across both hemispheres and between the central brain and the optic lobes. Tracing from a subset of photoreceptors to descending motor pathways illustrates how structure can uncover putative circuit mechanisms underlying sensorimotor behaviours. The technologies and open ecosystem reported here set the stage for future large-scale connectome projects in other species.
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