Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation
Yang Gao(Shenzhen Bay Laboratory), Jianan Li, Wenfeng Cheng(Peking University), Tian Diao(Peking University), Huilan Liu(Peking University), Yufei Bo(Peking University), Chang Liu(Peking University), Wei Zhou(Shenzhen Bay Laboratory), Minmin Chen(Shenzhen Bay Laboratory), Yuanyuan Zhang(Chinese Academy of Medical Sciences & Peking Union Medical College), Zhihua Liu(Chinese Academy of Medical Sciences & Peking Union Medical College), Weidong Han(Chinese PLA General Hospital), Rufu Chen(Guangdong Academy of Medical Sciences), Jirun Peng(Beijing Shijitan Hospital), Linnan Zhu(Peking University), Wenhong Hou(Guangdong Medical College), Zemin Zhang(Center for Life Sciences)
Cited by 221Open Access
Abstract
fibroblasts show potential anti-tumor functions in adjacent non-cancerous regions. Fibroblast-subtype compositions define patient subtypes with distinct clinical outcomes. This study advances our understanding of fibroblast biology and suggests potential therapeutic strategies for targeting specific fibroblast subsets in cancer treatment.
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