Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy
Jeremy Baldwin(National Cancer Institute), Christoph Heuser(Leibniz Institute for Immunotherapy), Tanmoy Saha(Harvard–MIT Division of Health Sciences and Technology), Roland Christian Schelker(University Hospital Regensburg), Dragana Slavkovic‐Lukic(Leibniz Institute for Immunotherapy), Nicholas Strieder(Leibniz Association), Inmaculada Hernandez-Lopez(Leibniz Association), Nisha Rana(University of Regensburg), Markus Barden(Leibniz Association), Fabio Mastrogiovanni(Leibniz Institute for Immunotherapy), Azucena Martín-Santos(Leibniz Institute for Immunotherapy), Andrea Raimondi(Vita-Salute San Raffaele University), Philip Z. Brohawn(AstraZeneca (Japan)), Brandon W. Higgs(Genmab (United States)), Claudia Gebhard(Leibniz Association), Veena Kapoor(National Institutes of Health), William G. Telford(National Institutes of Health), Sanjivan Gautam(National Institutes of Health), Maria Xydia(Leibniz Association), Philipp Beckhove(University Hospital Regensburg), Sina Frischholz(Friedrich-Alexander-Universität Erlangen-Nürnberg), Kilian Schober(Friedrich-Alexander-Universität Erlangen-Nürnberg), Zacharias Kontarakis(University of Zurich), Jacob E. Corn(ETH Zurich), Matteo Iannacone(Vita-Salute San Raffaele University), Donato Inverso(Vita-Salute San Raffaele University), Michael Rehli(University Hospital Regensburg), Jessica Fioravanti(National Cancer Institute), Shiladitya Sengupta(Harvard–MIT Division of Health Sciences and Technology), Luca Gattinoni(University Hospital Regensburg)
Cited by 191Open Access
Abstract
T cells mediated superior antitumor responses, prolonging animal survival. These findings establish intercellular mitochondrial transfer as a prototype of organelle medicine, opening avenues to next-generation cell therapies.
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