Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIA

Michelle E. Pizzo(Denali Therapeutics (United States)), Y. Joy Yu Zuchero(Denali Therapeutics (United States)), Isabel Becerra(Denali Therapeutics (United States)), Robert G. Thorne(Denali Therapeutics (United States)), Paul H. Weinreb(Biogen (United States)), René Meisner(OncoMed (United States)), Lu Shan(Denali Therapeutics (United States)), David Joy(Gladstone Institutes), Claire B. Discenza(Denali Therapeutics (United States)), Nathalie Khoury(Denali Therapeutics (United States)), Timothy Earr(Denali Therapeutics (United States)), Dominic M. Walsh(Biogen (United States)), Joseph Duque(Denali Therapeutics (United States)), Thierry Bussière(Biogen (United States)), Jason C. Dugas(Stanford University), Roni Chau(Denali Therapeutics (United States)), Johann Chow(Denali Therapeutics (United States)), Ana C. Amaral(Massachusetts General Hospital), Hilda Solanoy, Wanda Kwan(Denali Therapeutics (United States)), Ming Lye‐Barthel(Biogen (United States)), Amy Wing-Sze Leung(Denali Therapeutics (United States)), Jennifer A. Getz(Denali Therapeutics (United States)), Allisa Clemens(Denali Therapeutics (United States)), Pascal E. Sanchez(Denali Therapeutics (United States)), Joseph W. Lewcock(Denali Therapeutics (United States)), Kapil Gadkar(Sea Turtle Conservancy), Sarah L. DeVos(Denali Therapeutics (United States)), Hoang N. Nguyen(Denali Therapeutics (United States)), Edward D. Plowey(Biogen (United States)), Elliot R. Thomsen(Denali Therapeutics (United States)), Ryan J. Watts(Denali Therapeutics (United States)), Jennifer Sebalusky(Biogen (United States)), Mark S. Dennis(Denali Therapeutics (United States)), Jordan Abettan(Biogen (United States)), Meredith Calvert(Temasek Life Sciences Laboratory), Darren Chan(University Health Network), Do Jin Kim(Denali Therapeutics (United States)), Raymond K. Tong, Adam P. Silverman(Northwell Health), Elysia Roche(Denali Therapeutics (United States)), Laura Fusaro(Denali Therapeutics (United States)), Mihalis S. Kariolis(Denali Therapeutics (United States))
bioRxiv (Cold Spring Harbor Laboratory)
July 26, 2024
Cited by 13


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