Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing

Ming Zhu; Runda Xu; Junsong Yuan; Jiacheng Wang; Xiaoyu Ren; Tingting Cong; Yaxian You; Anji Ju; Longchen Xu; Huimin Wang; Peiyuan Zheng; Huiying Tao; Chunhua Lin; Honghao Yu; Juanjuan Du; Xin Lin; Wei Xie; Yinqing Li; Xun Lan

doi:10.1038/s41587-024-02307-y

Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing

Ming Zhu(King Center), Runda Xu(Center for Life Sciences), Junsong Yuan(McGovern Institute for Brain Research), Jiacheng Wang(Center for Life Sciences), Xiaoyu Ren(McGovern Institute for Brain Research), Tingting Cong(McGovern Institute for Brain Research), Yaxian You(Center for Life Sciences), Anji Ju(Center for Life Sciences), Longchen Xu(Center for Life Sciences), Huimin Wang(Center for Life Sciences), Peiyuan Zheng(McGovern Institute for Brain Research), Huiying Tao(Qingdao University), Chunhua Lin(Qingdao University), Honghao Yu(Guilin Medical University), Juanjuan Du(McGovern Institute for Brain Research), Xin Lin(Center for Life Sciences), Wei Xie(Center for Life Sciences), Yinqing Li(State Key Laboratory of Molecular Oncology), Xun Lan(King Center)

Nature Biotechnology

July 2, 2024

10.1038/s41587-024-02307-y

Cited by 46

Abstract

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