Suppression of T cell function by phosphoethanolamine, a metabolite enriched in tumor interstitial fluid
Yupeng Wang(University of Pittsburgh), Greg M. Delgoffe(University of Pittsburgh), Dayana B. Rivadeneira(University of Pittsburgh), Konstantinos Lontos(The University of Texas MD Anderson Cancer Center), Ronal M. Peralta(UPMC Hillman Cancer Center), Hardik Shah(University of Chicago), Chufan Cai(University of Chicago), Drew N. Wilfahrt(UPMC Hillman Cancer Center), Roya AminiTabrizi(University of Chicago), Alexander Muir(University of Chicago), Benjamin Cameron(University of Pittsburgh), Bingxian Xie(UPMC Hillman Cancer Center)
Cited by 5
Related Papers
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
|Nature Immunology|2011|1.1k
Tissue of origin dictates branched-chain amino acid metabolism in mutant<i>Kras</i>-driven cancers
|Science|2016|576
4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses
|The Journal of Experimental Medicine|2018|302
Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
|Nature Immunology|2022|254
An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance
|Nature Biotechnology|2020|152