Lipidome atlas of the adult human brain

Maria Osetrova; Anna Tkachev; Waltraud Mair; Patricia Guijarro Larraz; Olga Efimova; Ilia Kurochkin; Elena Stekolshchikova; Nikolay A. Anikanov; Juat Chin Foo; Amaury Cazenave‐Gassiot; Aleksandra Mitina; Polina Ogurtsova; Song Guo; Daria M. Potashnikova; А. А. Гулин; А. А. Васин; Anastasia Sarycheva; Gleb Vladimirov; Maria Fedorova; Yury Kostyukevich; Е. Н. Николаев; Markus R. Wenk; Ekaterina E. Khrameeva; Philipp Khaitovich

doi:10.1038/s41467-024-48734-y

Lipidome atlas of the adult human brain

Maria Osetrova(Skolkovo Institute of Science and Technology), Anna Tkachev(Skolkovo Institute of Science and Technology), Waltraud Mair(Skolkovo Institute of Science and Technology), Patricia Guijarro Larraz(Skolkovo Institute of Science and Technology), Olga Efimova(Skolkovo Institute of Science and Technology), Ilia Kurochkin(Skolkovo Institute of Science and Technology), Elena Stekolshchikova(Skolkovo Institute of Science and Technology), Nikolay A. Anikanov(Skolkovo Institute of Science and Technology), Juat Chin Foo(National University of Singapore), Amaury Cazenave‐Gassiot(National University of Singapore), Aleksandra Mitina(Skolkovo Institute of Science and Technology), Polina Ogurtsova(Skolkovo Institute of Science and Technology), Song Guo(Skolkovo Institute of Science and Technology), Daria M. Potashnikova(Lomonosov Moscow State University), А. А. Гулин(Semenov Institute of Chemical Physics), А. А. Васин(Lomonosov Moscow State University), Anastasia Sarycheva(Skolkovo Institute of Science and Technology), Gleb Vladimirov(Skolkovo Institute of Science and Technology), Maria Fedorova(Leipzig University), Yury Kostyukevich(Skolkovo Institute of Science and Technology), Е. Н. Николаев(Skolkovo Institute of Science and Technology), Markus R. Wenk(National University of Singapore), Ekaterina E. Khrameeva(Skolkovo Institute of Science and Technology), Philipp Khaitovich(Skolkovo Institute of Science and Technology)

Nature Communications

May 25, 2024

10.1038/s41467-024-48734-y

Cited by 99Open Access

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Abstract

Lipids are the most abundant but poorly explored components of the human brain. Here, we present a lipidome map of the human brain comprising 75 regions, including 52 neocortical ones. The lipidome composition varies greatly among the brain regions, affecting 93% of the 419 analyzed lipids. These differences reflect the brain's structural characteristics, such as myelin content (345 lipids) and cell type composition (353 lipids), but also functional traits: functional connectivity (76 lipids) and information processing hierarchy (60 lipids). Combining lipid composition and mRNA expression data further enhances functional connectivity association. Biochemically, lipids linked with structural and functional brain features display distinct lipid class distribution, unsaturation extent, and prevalence of omega-3 and omega-6 fatty acid residues. We verified our conclusions by parallel analysis of three adult macaque brains, targeted analysis of 216 lipids, mass spectrometry imaging, and lipidome assessment of sorted murine neurons.

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